Squamous cell dysplasia in the proximal rectum of three patients treated for ulcerative colitis on immunomodulators

Connolly, James G.; Goldstone, Stephen E.

doi:10.1007/s00384-016-2745-9

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Corticosteroids are used for short-term treatment and cannot bene t from long-term use because of the many complications associated with long-term use, such as osteoporosis and hypertension [23,24]. Long-term use of immunomodulators is not only toxic, but one case follow-up showed possible transformation into high-grade squamous intraepithelial lesions, which are precancerous [25]. Biologics such as anti-TNF drugs not only increase the risk of infection in UC patients, but may also present with various types of TB [26,27].…”

Section: Discussionmentioning

confidence: 99%

PVA enema ameliorates DSS-induced acute colitis in mice

Zhang

Kong

et al. 2023

Preprint

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Background Polyvinyl alcohol (PVA) solution is a biodegradable polymer material with the main component of glue. PVA can now be used in the medical field. Ulcerative colitis (UC) is a clinically intractable disease with persistent damage to the colonic epithelial mucosa as the main pathological change. The research aims to explore the therapeutic effect of PVA water solution on UC in mice. Methods The UC model was induced by dextran sulfate sodium, and the therapeutic effects of different concentrations of PVA water solution on the model mice were observed. Besides the changes in mouse body weight, clinical disease activity index, and colon length were recorded. Histopathological examination staining and inflammatory factors levels were used to evaluate the degree of colonic tissue damage and inflammation. Furthermore, mouse colon organoids were cultured, which were used to assess the effects of different concentrations of PVA aqueous solution on the number of organoids in vitro. Results We reported that treatment with PVA aqueous solution (1 mg/ml and 3 mg/ml) can significantly alleviate the weight loss of the colitis group, and dramatically improve histopathology scores, meanwhile the levels of inflammatory factors in intestinal mucosal tissue were decreased. It was also confirmed that PVA could greatly increase the number of colonic organoids in vitro. Conclusions In summary, PVA can relieve tissue damage and clinical symptoms of ulcerative colitis. We infer that the underlying mechanism may be related to promoting intestinal stem cell proliferation by PVA, which might in turn promote the repair of intestinal mucosal damage. This study might provide a new candidate for the clinical treatment of ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

PVA enema ameliorates DSS-induced acute colitis in mice

Zhang

Kong

et al. 2023

Preprint

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“…Corticosteroids, treated for short-term therapeutic interventions, are beset by a multitude of complications upon extended usage, encompassing osteoporosis and hypertension [ 22 , 23 ]. Previous case report revealed that, despite their therapeutic potential, the prolonged treatment of immunomodulatory agents might lead to the precancerous lesions such as high-grade squamous intraepithelial lesions [ 24 ]. While anti-TNF can be used for severe ulcerative colitis treatment, there’s a risk of recurrence if it is discontinued [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

PVA enema ameliorates DSS-induced acute colitis in mice

Zhang,

Kong,

et al. 2023

BMC Gastroenterol

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Background Ulcerative colitis (UC) represents a clinically challenging condition characterized by persistent damage to the colonic epithelial mucosa as the principal pathological feature. Polyvinyl alcohol (PVA) solution, primarily composed of glue, is a biodegradable polymer material that has found utility in the medical field. This research endeavors to investigate the therapeutic potential of PVA water solution in ameliorating UC in mice. Methods UC was induced in 48 C57BL/6 mice by administering 2.5% DSS in their diet for 6 days. Mice were treated with different concentrations of PVA (0.1 mg/ml PVA, 0.3 mg/ml PVA, 1 mg/ml PVA, 3 mg/ml PVA, 10 mg/ml PVA) enemas (n = 6). Disease Activity Index (DAI) and histologic score were evaluated for inflammation degree. Furthermore, mouse colon organoids were cultured, which were used to assess the effects of PVA on expansion in vitro. Results PVA aqueous solutions (1 mg/ml and 3 mg/ml) were able to alleviate the DAI in mice. By DAY 6, there was a significant 3/5-fold decrease in DAI within the 1 mg/ml PVA group (p = 0.02). Histopathology scores demonstrated improvements, while the levels of inflammatory factors in the intestinal mucosal tissue were reduced. Additionally, it was confirmed that PVA could promote the expansion of colonic organoids in vitro. Conclusions In summary, our investigation has yielded findings indicating that PVA holds the potential to ameliorate symptoms associated with colitis in murine subjects afflicted by DSS-induced colitis, primarily through its facilitation of intestinal stem cell expansion. This study might provide a new candidate for the clinical treatment of ulcerative colitis.

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Multiple drugs

2017

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Squamous cell dysplasia in the proximal rectum of three patients treated for ulcerative colitis on immunomodulators

Cited by 6 publications

References 11 publications

PVA enema ameliorates DSS-induced acute colitis in mice

PVA enema ameliorates DSS-induced acute colitis in mice

PVA enema ameliorates DSS-induced acute colitis in mice

Multiple drugs

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