Squamous Differentiation in Malignant Eccrine Poroma

Pena, J.L.B.; Suster, Saul

doi:10.1097/00000372-199310000-00016

Cited by 22 publications

(15 citation statements)

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“…The fact that the neoplasm had been present for 10 years with no dramatic increase in tumour size, and no regional or systemic dissemination, speaks in favour of an indolent clinical behaviour. The clinical characteristics of our case are similar to that reported by Peñ~a and Suster 4 as malignant eccrine poroma with squamous differentiation. The follow‐up in our case is, however, too short to evaluate the recurrence rate.…”

supporting

confidence: 88%

“…did, the convenience of grouping eccrine ductal carcinomas with predominantly squamous differentiation as a distinct subtype, our case indicates that these neoplasms may occur in younger patients than previously reported, and that a cystic ductal component (probably related to tumour compression) may account for variations in tumour size. The latter feature merits particular attention, given the longstanding clinical evolution of our case, as well as other eccrine carcinomas reported in the literature 4 .…”

mentioning

confidence: 59%

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Squamoid eccrine ductal carcinoma

Herrero¹,

Monteagudo²,

Jordá

et al. 1998

Histopathology

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supporting

confidence: 88%

mentioning

confidence: 59%

Squamoid eccrine ductal carcinoma

Herrero¹,

Monteagudo²,

Jordá

et al. 1998

Histopathology

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“…We have described three cases of eccrine ductal carcinoma with prominent squamoid differentiation that closely resembled an invasive squamous cell carcinoma. The phenomenon of squamous differentiation in eccrine dermal adnexal neoplasms has been previously observed in eccrine poroma 1 and porocarcinoma 3 , as well as in ductal eccrine carcinoma 6,7 . Squamous differentiation in eccrine adnexal neoplasms, when prominent, may introduce difficulties for diagnosis.…”

Section: Discussionmentioning

confidence: 63%

“…A variant of eccrine carcinoma with prominent squamoid differentiation is mentioned by Wick and Swanson 7 as a potential pitfall for the diagnosis of squamous cell carcinoma. Prominent squamous differentiation has also been described in eccrine porocarcinoma 3,6 . The presence of prominent squamoid differentiation in such lesions may lead to an erroneous interpretation of the lesion as a squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 88%

Squamoid eccrine ductal carcinoma

1997

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We describe three cases of a distinctive cutaneous adnexal neoplasm showing features of eccrine ductal differentiation that were characterized by a prominent squamoid component. The tumours presented as solitary dermal nodules on the head and neck areas and the extremities in elderly patients. Histologically, they were characterized by a prominent squamous proliferation with atypia, keratinous cyst formation and squamous eddies which seemed to merge with areas showing eccrine ductal differentiation, including ductular formations in continuity with eccrine ductal epithelium. Clinical follow‐up in one case showed multiple local recurrences over a period of 3 years despite complete surgical excision. Squamoid eccrine ductal carcinoma should be considered in the differential diagnosis of cutaneous adnexal neoplasms showing squamoid and ductal features of differentiation.

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“…Squamoid eccrine ductal carcinoma is a distinctive cutaneous adnexal tumor characterized by eccrine ductal differentiation with prominent squamous differentiation 3 and mentioned by Swanson and colleagues as a potential pitfall for the diagnosis of SCC, which generally shows a less aggressive nature than ECs 4 . A prominent squamous component has been described in a variety of eccrine tumors, including eccrine poroma, eccrine spiradenoma, and malignant eccrine poroma, as well as in eccrine ductal carcinoma 3–7 . Kohda and colleagues reported cases of a squamous component in benign and malignant eccrine gland tumors and divided these squamous components into three types according to their location, histologic architecture, and degree of cellular atypia 5 .…”

Section: Discussionmentioning

confidence: 99%