Squamous Differentiation of Epithelial-Like Formations in Glioblastoma and Gliosarcoma

Rubinstein, L. J.; Mørk, S.J.; Kepes, John J.; Uphoff, Dean F.

doi:10.1097/00005072-198605000-00043

Cited by 6 publications

(2 citation statements)

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“…The authors suggested that the pathological arrangement might help to distinguish the tumor from metastatic carcinomas, an interpretation in line with that of other authors [17]. Rubinstein et al noted that these arrangements are rare GBM variants and described tumors with papillary formation mimicking medulloepithelial-like formations [18].…”

Section: Discussionsupporting

confidence: 71%

Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Albanna

Schubert

Clusmann

et al. 2018

BJSTR

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Glioblastomas tend to be morphologically diverse. Although rare, pseudoepithelial components (adenoid or epithelioid) can be a diagnostic challenge. We describe a case of a 47-year-old female patient initially complaining of neck pain and dizziness. On neurological examination, an unsteady gait and memory disturbances were noted. MRI showed a contrast-enhancing lesion in the left temporal lobe without significant edema, suggesting the presence of cerebral metastasis. After complete resection of the tumor (as verified by early post-op MRI), the patient made an uneventful recovery. Based on extensive histopathological analyses, the tumor was diagnosed as epithelioid glioblastoma (E-GBM). Two months after concomitant radiation and chemotherapy, the patient developed severe neck pain, became dizzy and was confused. CSF examination confirmed tumor cells, and MRI of the spine showed diffuse dural contrast enhancement, suggesting extensive leptomeningeal spread. The patient passed away four months after the initial diagnosis. E-GBMs represent one of the least prevalent morphologic subtypes of glioblastoma. Although E-GBMs are difficult to detect and often do not present as high-grade gliomas, clinicians should be aware of the unusual patterns of these GBMs. E-GBM should be considered in the case of MRI findings without peripheral edema, and when newly diagnosed intracerebral masses arise without a known primary. In addition, we discuss our case in terms of previous reports on this condition.

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Section: Discussionsupporting

confidence: 71%

Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Albanna

Schubert

Clusmann

et al. 2018

BJSTR

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“…Such "search for a primary" may be very exacting in terms of discomfort and also financial cost, particularly for a patient who at that time is just recovering from a craniotomy. More recently, squamous differentiation of epithelial-like formations in glioblastoma as well as gliosarcomas has been observed by Dr. Rubinstein et al 35 These authors were able to demonstrate the simultaneous presence of glial fibrillary acidic protein as well as keratin in some of the epithelial-looking cell nests of glioblastomas (Figures 28, 29). In a recent publication Dr. Mandybur et al have again illustrated the transformation of glioma cells to epithelium-like masses in human gliomas, transplanted this time into nude mice.…”

Section: Epithelial Formations In Gliomasmentioning

confidence: 79%

Astrocytomas: Old and Newly Recognized Variants, Their Spectrum of Morphology and Antigen Expression

Kepes

1987

Can. j. neurol. sci.

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Abstract:The relationship between the morphology of astrocytomas and their prognosis is complex, with the localization of the tumour, the predominant cell type and the degree of anaplasia all playing an important part in determining the patient's future. Since many astrocytomas have a diversity of patterns, small needle biopsies taken from just one or a few areas may fail to elucidate the principal features of a given tumour. In addition to the astrocytoma subtypes listed in the WHO's International Histological Classification of brain tumours, new entities have been observed in the last few years. These include lipidized forms, such as the relatively benign pleomorphic xanthoastrocytoma and the highly malignant lipidized glioblastoma. Neoplastic astrocytes are capable of forming basal laminae and of phagocytosis, and often contain alpha-1-antitrypsin, features that may lead to confusing them with histiocytes. They may be arranged in a whorled pattern imitating meningiomas, their myxoid intercellular stroma may assume the morphology of cartilage and closely packed tumour cells in “epitheloid” astrocytomas come close to imitate metastatic carcinoma. Some astrocytomas contain cells indistinguishable from those of granular cell tumours of other tissues. The presence of reactive lymphocytes in astrocytomas and reactive astrocytes in malignant lymphomas can be the source of confusion between those two kinds of neoplasms.

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Ependymal and choroid plexus tumors. Cytokeratin and GFAP expression

Mannoji

Becker

1988

Cancer

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Twenty-six ependymal and 15 choroid plexus tumors were examined with monoclonal antibody against cytokeratin using the avidin-biotin-peroxidase complex (ABC) technique. Serial sections were examined with antisera to glial fibrillary acidic protein (GFAP). In five ependymal tumors (one ependymoma, two papillary ependymomas, and two primitive neuroectodermal tumors [PNEV with ependymal cells), a variable number of cytokeratin-positive cells were present. Most tumor cells (except two PNET) were positive with GFAP antisera. Many cytokeratin-positive cells were present in all choroid plexus tumors. GFAP-positive cells were present focally in six of 11 papillomas and in one of four carcinomas. Although their staining patterns and distribution were clearly different, focal coexistence of cytokeratin and GFAP was observed in six papillomas and two ependymal tumors. Thus, some ependymal tumors (especially papillary ependymomas and occasional PNET) and many choroid plexus tumors have de-monstrable positivity with antibody to cytokeratin, suggesting a transitional cell type with features of both ependyma and choroid plexus.

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Squamous Differentiation of Epithelial-Like Formations in Glioblastoma and Gliosarcoma

Cited by 6 publications

References 0 publications

Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Astrocytomas: Old and Newly Recognized Variants, Their Spectrum of Morphology and Antigen Expression

Ependymal and choroid plexus tumors. Cytokeratin and GFAP expression

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