Square-wave jerks and square-wave oscillations: treatment with valproic acid

Traccis, S.; Marras, M. A.; Puliga, M. V.; Ruiu, M. C.; Masala, P.G.; Carboni, A.; Aiello, I.; Pugliatti, Maura; Rosati, Giulio

doi:10.3109/01658109709044117

Cited by 11 publications

(3 citation statements)

References 18 publications

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“…Four of 5 patients with square-wave oscillations, probably a related fixation disturbance, showed an improvement on therapy with valproic acid [80]. In single cases, an improvement has been observed during treatment with propranolol (40-80 mg p.o.…”

Section: Treatmentmentioning

confidence: 89%

Therapeutic Considerations for Eye Movement Disorders

Straube¹

2007

Neuro-Ophthalmology

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Advances made in understanding the pathophysiology of eye movement disorders have only recently with the publication of the first well-planned studies been translated into better treatment strategies. The following chapter summarizes the pharmacological treatment options for a variety of oculomotor syndromes. Cortisone is useful, for example, for acute vestibular neuritis to improve the restitution of the labyrinthine function. For the widespread benign paroxysmal positioning nystagmus, a series of liberating movements that free the semicircular canal from the causative otoconia is now a well-established therapy. Treatment for the central vestibular syndrome of up- and downbeat nystagmus consists of drugs like the potassium canal blocker 4-aminopyridine, which influence the cerebellar circuits involved in the disorder's pathophysiology. Acquired pendular nystagmus, one of the oculomotor syndromes often caused by multiple sclerosis, results in the severe impairment of reduced visual acuity. Memantine, a weak NMDA antagonist, has now been proven effective here. Finally, anticonvulsants like carbamazepine are the drugs of choice for disorders involving a nerve-blood vessel contact that induces symptoms of vestibular paroxysmia or superior oblique myokymia.

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Section: Treatmentmentioning

confidence: 89%

Therapeutic Considerations for Eye Movement Disorders

Straube¹

2007

Neuro-Ophthalmology

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“…In addition to therapy for any underlying process such as tumour or encephalitis, treatment with immunoglobulins or prednisolone may be occasionally effective [70]. Four of five patients with square‐wave oscillations, probably a related fixation disturbance, showed an improvement on therapy with valproic acid [71] or in patients with hereditary spinocerebellar atxia on therapy with memantine 20 mg/daily [72]. In single cases, an improvement has been observed during treatment with propranolol (40–80 mg p.o.…”

Section: Recommendationsmentioning

confidence: 99%

Nystagmus and oscillopsia

Straube¹,

Bronstein

Straumann

2011

Euro J of Neurology

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The ocular motor system consists of several subsystems, including the vestibular ocular nystagmus saccade system, the pursuit system, the fixation and gaze-holding system and the vergence system. All these subsystems aid the stabilization of the images on the retina during eye and head movements and any kind of disturbance of one of the systems can cause instability of the eyes (e.g. nystagmus) or an inadequate eye movement causing a mismatch between head and eye movement (e.g. bilateral vestibular failure). In both situations, the subjects experience a movement of the world (oscillopsia) which is quite disturbing. New insights into the patho-physiology of some of the ocular motor disorders have helped to establish new treatment options, in particular in downbeat nystagmus, upbeat nystagmus, periodic alternating nystagmus, acquired pendular nystagmus and paroxysmal vestibular episodes/attacks. The discussed patho-physiology of these disorders and the current literature on treatment options are discussed and practical treatment recommendations are given in the paper.

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“…In addition to therapy for any underlying process such as tumor or encephalitis, treatment with immunoglobulins or prednisolone may be occasionally effective (Pless and Ronthal, 1996). Four of five patients with square‐wave oscillations, probably a related fixation disturbance, showed an improvement on therapy with valproic acid (Traccis et al. , 1997).…”

Section: Therapeutic Recommendationsmentioning

confidence: 99%

EFNS task force – therapy of nystagmus and oscillopsia

Straube¹,

Leigh

Bronstein

et al. 2004

Euro J of Neurology

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An overview of possible treatment options for oculomotor disorders that prevent clear vision is given. Downbeat nystagmus, upbeat nystagmus, seesaw nystagmus, periodic alternating nystagmus, acquired pendular nystagmus, and saccadic oscillations such as opsoclonus/ocular flutter are discussed. In addition, superior oblique myokymia and vestibular paroxysmia are reviewed. All treatment recommendations available in the literature are classified as class C only. In general, only some of the patients benefit from the treatment.

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Square-wave jerks and square-wave oscillations: treatment with valproic acid

Cited by 11 publications

References 18 publications

Therapeutic Considerations for Eye Movement Disorders

Therapeutic Considerations for Eye Movement Disorders

Nystagmus and oscillopsia

EFNS task force – therapy of nystagmus and oscillopsia

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