SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange

Buckenmaier, Kai; Rudolph, Matthias; Back, Christoph; Misztal, Tomasz; Bommerich, Ute; Fehling, P; Koelle, D.; Kleiner, R.; Mayer, Hermann A.; Scheffler, Klaus; Bernarding, Johannes; Plaumann, Markus

doi:10.1038/s41598-017-13757-7

Cited by 29 publications

(32 citation statements)

References 53 publications

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“…More quantitative studies of the polarization transfer process were performed by Buckenmaier et al with SQUID-MR. [70] The detector has to be cooled to 4 K limiting their operational area to surface coils and 10 mm distance from the sample. Despite the distance, SQUIDS are still roughly one order of magnitude more sensitive than conventional coils at 10 mT and two orders of magnitude than those at 0.5 mT.…”

Section: How To Make It Work: the Hyperpolarizer And Chemistry Of mentioning

confidence: 99%

Parahydrogen‐Based Hyperpolarization for Biomedicine

et al. 2018

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Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH ), which is inherently stable and long-lived. When brought into contact with another molecule, this "spin order on demand" allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH -based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.

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Section: How To Make It Work: the Hyperpolarizer And Chemistry Of mentioning

confidence: 99%

Parahydrogen‐Based Hyperpolarization for Biomedicine

et al. 2018

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“…[40] Much effort is being undertaken to bring SABRE to "life sciences", but despite considerable efforts, a clean, highly polarized, highly concentrated biologically relevant contrast agent was not produced yet. [27,35,36,[47][48][49] This observation illustrates that the transfer of pH 2 spin order to a substrate at the low magnetic field can be greatly improved by using more targeted polarization transfer techniques discussed elsewhere. Here, we report the opposite effect: we discovered that in SABRE experiments at low magnetic fields various multiple spin orders are hyperpolarized.…”

Section: Introductionmentioning

confidence: 68%

“…J-coupling constants were taken from literature or were estimated, [35] excitation pulses were treated as ideal rotations with zero duration (hard pulses), and spin relaxation was neglected. J-coupling constants were taken from literature or were estimated, [35] excitation pulses were treated as ideal rotations with zero duration (hard pulses), and spin relaxation was neglected.…”

Section: Methodsmentioning

confidence: 99%

“…For the experiments, B p is set to the optimal strength for the SABRE hyperpolarization of 19 F of the ligands, 5.2 mT, [35] and reduced to B 0 = 91 μT for observation of the free induction decay (FID) (see Scheme 1a and Figure S1). The polarizing coil enables fast switching ( � 10 ms) between B p and B 0 and is placed inside a three-layered μ-metal shield.…”

Section: Experimental Section Hardwarementioning

confidence: 99%

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Multiple Quantum Coherences Hyperpolarized at Ultra‐Low Fields

et al. 2019

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The development of hyperpolarization technologies enabled several yet exotic NMR applications at low and ultra-low fields (ULF), where without hyperpolarization even the detection of a signal from analytes is a challenge. Herein, we present a method for the simultaneous excitation and observation of homo-and heteronuclear multiple quantum coherences (from zero up to the third-order), which give an additional degree of freedom for ULF NMR experiments, where the chemical shift variation is negligible. The approach is based on heteronuclear correlated spectroscopy (COSY); its combination with a phasecycling scheme allows the selective observation of multiple quantum coherences of different orders. The nonequilibrium spin state and multiple spin orders are generated by signal amplification by reversible exchange (SABRE) and detected at ULF with a superconducting quantum interference device (SQUID)-based NMR system.[a] Dr.

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“…These demonstrations were targeted towards potential pulmonary functional imaging to enable physiology research and diagnosis. Other ULF‐MRI hyperpolarization demonstrations have included techniques based on parahydrogen …”

Section: Current State Of the Artmentioning

confidence: 99%

Accessible magnetic resonance imaging: A review

Geethanath

Vaughan

2019

Magnetic Resonance Imaging

153

139

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The role of MRI in diagnostics, prognostics, and discoveries in basic sciences has been well established. However, access to this life‐saving technology is largely restricted to countries in upper‐middle to high‐income groups. In this article, we collate recent global MR scanner density data and group them into six geographical regions based on the WHO classification. We then analyze these data with respect to demographic factors such as population size, life expectancy, the percentage of internet users, and World Bank income grouping. We map these demographic factors to five dimensions or characteristics of accessible MRI, adapting definitions from the healthcare literature. With this background, the study then reviews recent demonstrations of accessible MRI categorized based on main magnetic field strength. We describe demonstrated examples for each of these categories, ranging from ultralow‐field to ultrahigh‐field MRI. Lastly, we review MR methods and associated developments impacting accessible MRI such as increasing/augmenting MR awareness and local expertise, incorporating hardware‐cognizant methods, rapid quantitative imaging, and leveraging innovations from adjacent fields. Level of Evidence: 5 Technical Efficacy Stage: 6 J. Magn. Reson. Imaging 2019.

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SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange

Cited by 29 publications

References 53 publications

Parahydrogen‐Based Hyperpolarization for Biomedicine

Parahydrogen‐Based Hyperpolarization for Biomedicine

Multiple Quantum Coherences Hyperpolarized at Ultra‐Low Fields

Accessible magnetic resonance imaging: A review

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