2003
DOI: 10.1073/pnas.2336149100
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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

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Cited by 499 publications
(540 citation statements)
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References 43 publications
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“…Src-family kinases can bind directly and specifically to individual integrin β tails [6]. For example, c-Src binds directly to the β3 tail and clustering β3 integrins increases Src activation [6].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Src-family kinases can bind directly and specifically to individual integrin β tails [6]. For example, c-Src binds directly to the β3 tail and clustering β3 integrins increases Src activation [6].…”
Section: Discussionmentioning
confidence: 99%
“…These changes have been attributed to the regulation of cytoplasmic tyrosine kinases, FAK and Src, by integrins [9,10]. Both FAK and Src can bind directly to the integrin β tail [6,16]. Thus, Tac-β1 may titrate FAK and/or Src from endogenous β tails and prevent their activation by integrin engagement.…”
Section: Tac-β1 Inhibits the Adhesion-induced Phosphorylation Of Fakmentioning
confidence: 99%
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“…Loss of c-Src, in genetically deficient mouse models, leads to defects in ␤ 3 integrin signaling in platelets (10). For ␣ v ␤ 3 integrin signaling, the mechanism by which c-Src becomes activated during integrin signaling involves a direct interaction between the c-Src Src homology 3 domain and the C-terminal tail of the ␤ 3 chain (11). Clustering of ␤ 3 integrins in vivo activates c-Src leading to adhesion-dependent phosphorylation of Syk and other downstream signaling events.…”
mentioning
confidence: 99%
“…RhoA/ROCK-dependent inactivation of MLC phosphatase and phospholipase C (PLC)/Ca 2+ /calmodulin-dependent activation of MLC kinase (36). Interestingly, the RhoA activity can be suppressed by β3-associated Src catalyzing an activating phosphorylation of RhoA GAP (37), while the β1 cytoplasmic domain does not bind Src (38). This is consistent with lower RhoA activity after adhesion mediated by αvβ3 compared to α5β1 (39).…”
Section: Integrin Type-specific Signalsmentioning
confidence: 53%