SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease

Chao, Chih-Chang; Huang, Chuen-Lin; Cheng, Jing-Jy; Chiou, Chun-Tang; Lee, I-Jung; Yang, Ying-Chen; Hsu, Ting-Huang; Yei, Chia-En; Lin, Pei-Ying; Chen, Jih Jung; Huang, Nien-Tsu

doi:10.1016/j.redox.2022.102534

Cited by 18 publications

(3 citation statements)

References 96 publications

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“…Many compounds exert their anti-oxidant neuroprotective effects through Keap1-Nrf2 activation [ [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] ]. Consequently, it was tested whether the observed anti-oxidant effects of Oenin and Myrtillin in N2a22L cells also depended on Keap1-Nrf2 induction.…”

Section: Resultsmentioning

confidence: 99%

“…While Oenin didn't affect Nrf2 expression levels, it managed to activate the Keap1-Nrf2 pathway (albeit less effectively compared to Myrtillin). Indeed, the important step for the activation of Keap1-Nrf2 target genes is nuclear translocation of Nrf2 [ 70 , 73 , 75 , 114 , 134 , 135 ]. As a result, one potential explanation for the activity of Oenin is that it successfully triggered the nuclear translocation of Nrf2, but due to the fact that it didn't lead to upregulation of Nrf2 itself, the activation of the Keap1-Nrf2 pathway was less potent.…”

Section: Discussionmentioning

confidence: 99%

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Αnti-prion effects of anthocyanins

Christoudia,

Bekas,

Kanata

et al. 2024

Redox Biology

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Αnti-prion effects of anthocyanins

Christoudia,

Bekas,

Kanata

et al. 2024

Redox Biology

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“…[ [131][132][133][134][135][136][137][138][139][140][141][142][143] : the key feature is present; : the key feature is not present.…”

Section: Rotenonementioning

confidence: 99%

Parkinson’s Disease: Exploring Different Animal Model Systems

Khan

Hasan

Haque

2023

IJMS

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Disease modeling in non-human subjects is an essential part of any clinical research. To gain proper understanding of the etiology and pathophysiology of any disease, experimental models are required to replicate the disease process. Due to the huge diversity in pathophysiology and prognosis in different diseases, animal modeling is customized and specific accordingly. As in other neurodegenerative diseases, Parkinson’s disease is a progressive disorder coupled with varying forms of physical and mental disabilities. The pathological hallmarks of Parkinson’s disease are associated with the accumulation of misfolded protein called α-synuclein as Lewy body, and degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) area affecting the patient’s motor activity. Extensive research has already been conducted regarding animal modeling of Parkinson’s diseases. These include animal systems with induction of Parkinson’s, either pharmacologically or via genetic manipulation. In this review, we will be summarizing and discussing some of the commonly employed Parkinson’s disease animal model systems and their applications and limitations.

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The potential role of the SIRT1‐Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress

Zheng,

Zhang,

et al. 2024

Cell Biology International

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Hidden hearing loss (HHL) is characterized by normal audiometric thresholds but impaired auditory function, particularly in noisy environments. In vivo, we employed auditory brainstem response (ABR) testing and ribbon synapses counting to assess changes in mouse hearing function, and observed the morphology of hair cells through scanning electron microscopy. SRT1720 was administered to the cochlea via round window injection. In vitro, western blot analysis and RT‐qPCR were used, and Lenti‐shNrf2 was used to knockdown Nrf2 expression. In addition, various oxidative stress indicators were detected by immunofluorescence, kit‐based assays, and flow cytometry. ABR measurement of HHL mouse showed a significant increase in hearing threshold, as well as a decrease and delay in the I wave amplitude and latency on the first day after noise exposure. Histological observation showed a significant loss of ribbon synapses and stereocilia lodging. HHL mice exhibited oxidative stress, which was reduced by pretreatment with SRT1720. Additionally, SRT1720 could reduce hydrogen peroxide‐induced oxidative stress in HEI‐OC1 cells through activating the SIRT1/Nrf2 pathway. Subsequent experiments with Nrf2 knockdown confirmed the importance of this pathway. findings highlight oxidative stress as the primary contributor to HHL, with the SIRT1/Nrf2 signaling pathway emerging as a promising therapeutic target for alleviating HHL.

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SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease

Cited by 18 publications

References 96 publications

Αnti-prion effects of anthocyanins

Αnti-prion effects of anthocyanins

Parkinson’s Disease: Exploring Different Animal Model Systems

The potential role of the SIRT1‐Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress

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