Sry‐related high‐mobility‐group/HMG box 10 (SOX10) as a sensitive marker for triple‐negative breast cancer

Abstract

Sry-related high-mobility-group/HMG box 10 (SOX10) as a sensitive marker for triple-negative breast cancer Aims: Confirmation of a breast origin for triple-negative breast cancer (TNBC) is sometimes problematic. The traditional breast markers GATA-binding protein 3 (GATA3), mammaglobin (MGB) and gross cystic disease fluid protein 15 (GCDFP15) have shown limitations in identifying TNBC. Here, we aimed to examine the diagnostic potential of the newly proposed TNBC marker, Sry-related high-mobility-group/HMG box 10 (SOX10). Methods and results: We analysed and compared SOX10 expression with GATA3, MGB and GCDFP15 expression in a test cohort of 1838 invasive breast cancers (IBCs) by using tissue microarrays. The findings from the test cohort were further examined with a validation cohort of 42 TNBCs in whole sections. The overall expression rates of SOX10, GATA3, MGB and GCDFP15 were 6.9%, 83.1%, 47.0%, and 34.8%, respectively. Among the TNBCs within this cohort, the expression rates of SOX10, GATA3, MGB and GCDFP15 were 31.3%, 34.5%, 27.9%, and 25.2%, respectively. SOX10 was strongly associated with TNBC (P < 0.001), whereas all other traditional markers were associated with non-TNBC (P < 0.001 for all). In addition, SOX10 was more correlated to basal-like breast cancer (BLBC) (P = 0.001) than five-marker-negative subtype among the TNBCs. A high expression rate of SOX10 (81%) was confirmed in the validation cohort. Additionally, SOX10 expression was inversely correlated with GATA3 and GCDFP15 expression, so they may complement each other in TNBC detection. The SOX10-GATA3 combination yielded a sensitivity of 60.3% for TNBC detection in the test cohort. Conclusion: SOX10 is a reliable marker for identifying TNBC, and complements GATA3. The SOX10-GATA3 combination may be used as a sensitive TNBC marker.

S‐100 protein and SOX10‐positive breast carcinoma mimicking metastatic melanoma

“…More recently, GATA3 staining has been shown to be an effective and sensitive complementary marker when attempting to trace the origin of metastatic breast cancer, 8,14,15 and was also strongly positive in our case.…”

“…In addition, the lymph node showed a more even distribution of cells, and occasional scattered calcifications that are more commonly seen in breast carcinomas. More recently, GATA3 staining has been shown to be an effective and sensitive complementary marker when attempting to trace the origin of metastatic breast cancer, 8,14,15 and was also strongly positive in our case.…”

SOX10 Knockdown Inhibits Melanoma Cell Proliferation via Notch Signaling Pathway

“… 30 Moreover, Jamidi et al indicated that SOX10 protein has high level in BRCA, which could be a sensitive marker for BRCA patients. 31 The main reason might lie in the existence of some post-transcriptional regulation for SOX10 in BLCA and BRCA. There are few studies on SOX10 in other tumors, so the function and mechanism of SOX10 are unclear in COAD, ESCA, PRAD, READ and TGCT.…”

Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples

“…In this regard, SOX-10 has been reported to be commonly positive in GATA3-negative TNBC metastases [ 28 ]. The combination of SOX-10 and GATA3 yielded a sensitivity of about 60% for the identification of TNBC in a recent study investigating >1800 cases [ 29 ]. The combination of GATA3 and SOX-10 staining has been proven to be useful to identify mammary origin in several previous studies [ 30 , 31 , 32 , 33 ].…”