SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus

Billaut-Mulot, Odile; Cocude, Cécile; Kolesnitchenko, V.; Truong, Marie‐José; Chan, Edward K. L.; Hachula, Eric; Tribonnière, Xavier de la; Càpron, André; Bahr, George M.

doi:10.1172/jci13469

Cited by 25 publications

(29 citation statements)

References 48 publications

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“…It has been reported that autoantibodies to TRIM68 are frequently found in the sera of patients with Sjögren's syndrome (19). However, the clinical significance of these autoantibodies in human cancers has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

“…TRIM family proteins are involved in a broad range of biological processes, and consistently, their alterations result in diverse pathologic conditions, such as genetic diseases, viral infection, and cancer development (18). It has been reported that TRIM68 is one of the autoantigens associated with Sjögren's syndrome and is a new diagnostic marker for Sjögren's syndrome (19). However, the function of TRIM68 has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells

et al. 2008

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The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors that mediate the action of androgen. AR plays an important role in normal development of the prostate, as well as in the progression of prostate cancer. AR is regulated by several posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. In this study, we found that the putative E3 ubiquitin ligase TRIM68, which is preferentially expressed in prostate cancer cells, interacts with AR and enhances transcriptional activity of the AR in the presence of dihydrotestosterone. We also found that TRIM68 functionally interacts with TIP60 and p300, which act as coactivators of AR, and synergizes in the transactivation of AR. Overexpression of TRIM68 in prostate cancer cells caused an increase in secretion of prostate-specific antigen (PSA), one of the most reliable diagnostic markers for prostate cancer, whereas knockdown of TRIM68 attenuated the secretion of PSA and inhibited cell growth and colony-forming ability. Moreover, we showed that TRIM68 expression is significantly up-regulated in human prostate cancers compared with the expression in adjacent normal tissues. These results indicate that TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer. [Cancer Res 2008;68(9):3486-94]

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells

et al. 2008

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“…TRIM21 also targets other factors that are responsible for type-I IFN activation, including IRF-5, IRF-7 and IRF-8, for degradation through proteasomal or, thus far, unknown mechanisms (Higgs et al, 2008(Higgs et al, , 2010Espinosa et al, 2009;Yoshimi et al, 2009;Young et al, 2011;Lazzari et al, 2014). TRIMs are often described as autoantigens in autoimmune diseases and cancers, including TRIM21 and TRIM68 in SLE and Sjögren syndrome (Der et al, 1998;Billaut-Mulot et al, 2001), TRIM33 in dermatomyositis and the associated paraneoplastic phenomena (Targoff et al, 2006;Fujimoto et al, 2012), TRIM19 in primary biliary cirrhosis (Stinton et al, 2011), and TRIM28 in colon cancer (Kijanka et al, 2010;Hector et al, 2012) and dermatomyositis (Satoh et al, 2012). Furthermore, TRIMs as a protein family have been associated with the regulation of type-I IFN responses (Versteeg et al, 2013), in keeping with relationships described for TRIM21 above .…”

Section: Role Of Trim-directed Precision Autophagy In Diseasementioning

confidence: 99%

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

Kimura

Mandell

Deretić

2016

Journal of Cell Science

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Selective autophagy entails cooperation between target recognition and assembly of the autophagic apparatus. Target recognition is conducted by receptors that often recognize tags, such as ubiquitin and galectins, although examples of selective autophagy independent of these tags are emerging. It is less known how receptors cooperate with the upstream autophagic regulators, beyond the well-characterized association of receptors with Atg8 or its homologs, such as LC3B (encoded by MAP1LC3B), on autophagic membranes. The molecular details of the emerging role in autophagy of the family of proteins called TRIMs shed light on the coordination between cargo recognition and the assembly and activation of the principal autophagy regulators. In their autophagy roles, TRIMs act both as receptors and as platforms ('receptor regulators') for the assembly of the core autophagy regulators, such as ULK1 and Beclin 1 in their activated state. As autophagic receptors, TRIMs can directly recognize endogenous or exogenous targets, obviating a need for intermediary autophagic tags, such as ubiquitin and galectins. The receptor and regulatory features embodied within the same entity allow TRIMs to govern cargo degradation in a highly exact process termed 'precision autophagy'.

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“…TRIM68, an autoantigen in Sjogren's Syndrome and SLE, is also similarly exposed [43]. Several studies have reported the link between viral infection and the development of autoreactive antibodies and a number of these have demonstrated the production of antibodies specific to TRIM family members [2].…”

Section: Trims As Autoantigensmentioning

confidence: 99%

Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?

2011

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SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus

Cited by 25 publications

References 48 publications

TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells

TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?

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