To God, who is the witness of my successes and failures, the power inside me that motivates me to overcome the obstacles and give my best, who guides my life and provides me the happiest moments. God be glory everlasting.To my mother, whom with her sacrifices, advice, help and words of encouragement, has always helped and given me the enough force to follow ahead, the person who I have fought with since child, my constant example and the being for who I have done everything in my life, the person I always want to see happy.To my family, for teaching me the right way to be a good person and an excellent professional. Especially to my grandparents Virgilio and Rosa, for being my second parents, for all values taught and for instilling in me the thinking of fighting to reach my dreams.To all the new friends that I met during my stay in Brazil: Isnardo, Victor, Renan, Letícia, Clarice, Juan, Erlon and Marcelo, and the ones who I already knew: Laura and Nayla; who with I shared the good and the not-as-good moments.To all the members of Mendeleev House, for becoming my second family during these two years of study.To all my teachers and mentors. ACKNOWLEDGMENTS I would like to thank the University of Campinas (UNICAMP), the Department of Energy (DEP-FEM-UNICAMP/Brazil) and the Center of Petroleum Studies (CEPETRO-UNICAMP/Brazil), for the opportunity of conducting this research. Especial thanks to my advisor Prof. Ph.D. Denis José Schiozer and my co-advisor João Carlos von Hohendorff Filho, for the constant help, suggestions, patience and exigency. For sharing with me their knowledge and experience. Thanks to all the organizations involved and that supported this work: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Energi Simulation and Petrobras within the ANP R&D tax as "commitment to research and development investments". Thanks to the Research Group in Reservoir Simulation and Management (UNISIM-UNICAMP/Brazil).In addition, special thanks to Computer Modelling Group (CMG) for software licenses."Many of life's failures are people who did not realize how close they were to success when they gave up".