ß-Thalassemia Major: Experience at King Fahad Hofuf Hospital, Al-Hassa, Saudi Arabia

Laditan, A. A. O.; El-Agib, Mohamed Amin; Al-Naeem, Saad; Georgeos, Michael; Khabour, Sameera

doi:10.5144/0256-4947.1996.560

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…These include neurological disorders, imbalances in electrolytes, viral infections, developmental delays, and elevated levels of cytokines [2]. Similar to Joshi-Batajoo et al [35], Laditan et al [45], and Tavassoli et al [36], none of the patients with BM had meningeal irritation signs in our study, implying that the lack of these signs does not exclude BM in children. Clinicians should not rely solely on physical signs in this regard.…”

Section: Discussionsupporting

confidence: 73%

Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination

Shiva,

Khanzadeh,

Shohanizad

et al. 2023

J Exp Neurol

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Introduction: One of the most significant current discussions in pediatrics is whether lumbar puncture (LP) should be performed in children with febrile seizure (FS) as in the past. Objectives: We compared the prevalence of meningitis among FS children before and after the pentavalent vaccine to determine the importance of the LP in these children. Methods: We performed a retrospective cross-sectional study on the prevalence and etiology of bacterial meningitis (BM) in 1314 children with FS before and after pentavalent vaccination. Results: We found that complex FS was more prevalent in patients aged under 12 months compared to other patients. The peak incidence of aseptic meningitis and BM was in the age group of 12- to18- and 18- to 36-month-old, respectively (P value <0.001 and <0.05, respectively). Children with complex FS had a significantly higher rate of BM and a lower rate of seizure recurrence than those with simple FS (P value <0.05). There was a significant relationship between getting the pentavalent vaccine and reducing the prevalence of BM and Hib-induced BM, but no SP-induced BM (P value <0.05 and 0.05 and 0.104, respectively). Conclusion: This study offers some insights into the effectiveness of the pentavalent vaccine. In addition, the low prevalence of BM in vaccinated FS cases does not support strong recommendations for LP in FS children.

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Section: Discussionsupporting

confidence: 73%

Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination

Shiva,

Khanzadeh,

Shohanizad

et al. 2023

J Exp Neurol

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“…The reduction in blood transfusion requirements from every 2 weeks before splenectomy to every 4 weeks afterwards and the reduction of annual transfusion requirements by 60% are consistent with other reports. 13 All the patients developed thrombocytosis ranging from 500,000 to 1,000,000/mm 3 but required no intervention, as observed by Sumer et al 9 There were no deaths among our children.…”

Section: Discussionsupporting

confidence: 57%

“…10,11 The prevalence of splenectomy among our children with thalassaemia is 32%, similar to other reports from Saudi Arabia. 12,13 Some patients included in the study attended before the establishment of the thalassaemia centre and were not on the hypertransfusion regimen, and some showed poor compliance, resulting in signi cant splenomegaly and hypersplenism. There were no signi cant sex differences.…”

Section: Discussionmentioning

confidence: 99%

Splenectomy in thalassaemia major: experience at Madina Maternity and Children's Hospital, Saudi Arabia

2001

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Eighteen (32%) of 56 children with thalassaemia major, whose ages ranged from 5 to 12 years (mean 8.8), underwent splenectomy at Madina Maternity and Children's Hospital, Saudi Arabia during the period January 1992 to December 1999. This retrospective study was undertaken with the aim of discovering the outcome. The indications for splenectomy were increased transfusion requirements and massive splenomegaly in 17 children and splenic abscess in one. Polyvalent pneumococcal and Haemophilus influenza vaccines were not available and all the children therefore received intramuscular benzathine penicillin prophylaxis prior to surgery and oral penicillin prophylactically afterwards. Post-splenectomy septicaemia did not occur. The mean transfusion requirement reduced from 2 to 4 weeks and the mean pre-transfusion haemoglobin rose from 6 to 9 g/dl. There were no deaths. We conclude that splenectomy can be performed safely in children over 5 years of age with thalassaemia, and that pre- and post-operative penicillin can be given prophylactically in the absence of the recommended vaccines.

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“…Jaundice and failure to thrive result in growth retardation and recunent attacks of inf'ections, which are due to impaired neurophil chemotaxis and altered T and B lymphocytes percentages. Thalassaemia patients suffer lrom repeated attack of infection by Yersinia microorganism enhanced by iron overload and immunological defect (2,5,6). Also the measurements of the activity of enzymes in blood are considered a good value in the diagnosis and management and in the monitoring of the case progress of thalassaemia major (7).…”

Section: Introductionmentioning

confidence: 99%

Certain Serum Enzymes Study of P-Thalassaemia Major Among Mosul Population

H.,

M.M.,

2023

Tikrit J. Pharm. Sci.

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Ninety-seven blood samples of the P-thalassaemia major were collected from patients registered in Mosul thalassemic center (lbn Al-Ather pediatric hospital ) for the period 2001-2002, distributed in 52 males and 45 females aged 3.5-24.0 yrs old, and 87 blood samples of apparently healthy volunteers aged 3.5-24.0 yrs old too, distributed in 56 males and 31 females for the same aged and the period time . Hb cone., sGPT, sGOT, and ALP values were determined in addition to the age estimation for the two trails. Statistical analysis, show there were significant differences (p<0.05) within Hb cone. of the normal individuals aged 3.5-6.0 and 18.0-24.0 yrs old. The Hb means cone. of both P-thalassaemia major and normal (control) were directly proportional to the sGPT and sGOT. while the Hb mean cone. of the P-thalassaemia major only was directly proportional to the ALP. The sGPT (17.64 u/1), sGOT (13.99 u/1), and ALP (16.43 u/1) values of the P-thalassaemia major was higher than that values ( 4.74 u/1 , 10.95 u/1, and 4.65 u/1 respectively) of the normal individuals .

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ß-Thalassemia Major: Experience at King Fahad Hofuf Hospital, Al-Hassa, Saudi Arabia

Cited by 6 publications

References 14 publications

Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination

Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination

Splenectomy in thalassaemia major: experience at Madina Maternity and Children's Hospital, Saudi Arabia

Certain Serum Enzymes Study of P-Thalassaemia Major Among Mosul Population

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