SS32 Endovascular Repair of Postdissection Aneurysms Involving the Thoracoabdominal Aorta and Arch

Abstract

separated into intima/media and adventitia wall layers, and analyzed with Affymetrix HTA 2.0 microarrays. The aortas were segmented from the CTAs into three-dimensional digital models, which were then subjected to finite-element analysis (FEA) without informing the software (VASCOPS A4clinics Research Edition) about age, gender, family history, or blood pressure. Peak wall rupture index (PWRI), derived from the FEA, was used as a marker of biomechanical rupture risk. Differential gene expression, adjusted for age and gender, was studied with R software. Enriched gene ontology processes were examined for annotated transcripts with the GOrilla and REVIGO online tools.Results: No transcript was significantly associated with PWRI after 5% false discovery rate correction was performed, in either media or adventitia. However, there were 1203 and 872 transcripts associated with PWRI at a nominal P of <.05 in media and adventitia, respectively. Analysis of enriched biological processes using the entire annotated transcript list ranked by fold-change revealed that extracellular matrix and structure organization in the media and nucleic acid metabolism and RNA metabolism in the adventitia were the most enriched biological processes in aneurysms with high PWRI.Conclusions: These results suggest that biomechanical rupture risk associates with expression of extracellular matrix genes as well as the level of bulk gene activity.

Optimization schemes for endovascular repair with parallel technique based on hemodynamic analyses

“…Thus, in clinical operations, octopus grafts are often constructed based on available device, and more importantly, selection of length and diameter of the SGs is possible. Although the octopus technique can be successfully applied in a number of patients, its mid‐term and long‐term outcomes need to be further determined, and stenting plan needs to be quantitatively studied . In the current patient case, the prognosis is not satisfactory in long‐term follow‐up.…”