SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and
Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/
mTOR Signaling Pathways
Jinling Zhou,
Jian Luo,
Rizhi Gan
et al.
Abstract:Background:
Saponin of Schizocapsa plantaginea Hance I (SSPH I),a bioactive
saponin found in Schizocapsa plantaginea, exhibits significant anti-proliferation and antimetastasis
in lung cancer.
Objective:
To explore the anti-metastatic effects of SSPH I on non-small cell lung cancer
(NSCLC) with emphasis on epithelial-mesenchymal transition (EMT) both in vitro and vivo.
Methods:
The effects of SSPH I at the concentrations of 0, 0.875,1.75, and 3.5 μM on A549 and
PC9 lung cancer cells were evaluated using co… Show more
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