ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

Zhang, Xian; Xia, Yang; Chen, Ming; Zheng, Shaolie; Li, Jinyuan; Lin, Shaoqiang; Wang, Xiaoyu

doi:10.3892/mmr.2019.10712

Cited by 11 publications

(11 citation statements)

References 42 publications

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“…In this regard, Yoshihama et al [ 8 ] also reported that the KD of ST3GAL4 in lung metastatic H1299 cells inhibit sLe x expression reducing cell adhesion to HUVEC cells, which suggests its potential as a target for cell metastasis. In ovarian cancer, ST3GAL3 KD sensitized ovarian cancer cells to cisplatin and paclitaxel induced apoptosis [ 55 , 56 ]. Intriguingly, the induction of epithelial-mesenchymal transition (EMT) in colon cancer led to the upregulation of FUT3, ST3GAL3 and ST3GAL4, which are implicated in the final steps of the biosynthesis of sLe x/a , suggesting a significant link between those Lewis antigens and EMT in colon carcinoma [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Guerrero

Miró

Wong

et al. 2020

IJMS

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Aberrant sialylation is frequently found in pancreatic ductal adenocarcinoma (PDA). α2,3-Sialyltransferases (α2,3-STs) ST3GAL3 and ST3GAL4 are overexpressed in PDA tissues and are responsible for increased biosynthesis of sialyl-Lewis (sLe) antigens, which play an important role in metastasis. This study addresses the effect of α2,3-STs knockdown on the migratory and invasive phenotype of PDA cells, and on E-selectin-dependent adhesion. Characterization of the cell sialome, the α2,3-STs and fucosyltransferases involved in the biosynthesis of sLe antigens, using a panel of human PDA cells showed differences in the levels of sialylated determinants and α2,3-STs expression, reflecting their phenotypic heterogeneity. Knockdown of ST3GAL3 and ST3GAL4 in BxPC-3 and Capan-1 cells, which expressed moderate to high levels of sLe antigens and α2,3-STs, led to a significant reduction in sLex and in most cases in sLea, with slight increases in the α2,6-sialic acid content. Moreover, ST3GAL3 and ST3GAL4 downregulation resulted in a significant decrease in cell migration and invasion. Binding and rolling to E-selectin, which represent key steps in metastasis, were also markedly impaired in the α2,3-STs knockdown cells. Our results indicate that inhibition of ST3GAL3 and ST3GAL4 may be a novel strategy to block PDA metastasis, which is one of the reasons for its dismal prognosis.

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Section: Discussionmentioning

confidence: 99%

Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Guerrero

Miró

Wong

et al. 2020

IJMS

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“…Indeed, the expression of ST3GAL3 in breast cancer was found to be associated with poor prognosis (90). ST3Gal3 has also been associated with paclitaxel and cisplatin resistance in ovarian cancer cells (91,92).…”

Section: St3gal3mentioning

confidence: 99%

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

et al. 2021

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Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.

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“… 30 Furthermore, the endocervical adenocarcinoma cell lines HO‐8910 (HeLa derivative) and HO‐8910 PM (HeLa derivative) expressed increased mRNA levels of ST3Gal‐3 and were more frequently resistant to chemotherapy medications cisplatin and paclitaxel when compared to SK‐OV‐3 cells, with low mRNA levels of α2,3‐sialyltransferase. High dose cisplatin could downregulate ST3Gal‐3 mRNA expression levels and enhance the number of apoptotic cells in both SK‐OV‐3 and HO‐8910 PM cells 42,60,61 . A study of Wichert et al found the correlation between high ST6Gal‐1 mRNA levels and lymphovascular invasion and reduced survival 32 …”

Section: Resultsmentioning

confidence: 99%

Sialic acids in gynecological cancer development and progression: Impact on diagnosis and treatment

Berghuis

Pijnenborg

Boltje

et al. 2021

Intl Journal of Cancer

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Gynecological cancers are in the top 10 of most common cancers in women. Survival and outcome are strongly related to the stage at diagnosis. Therefore, early diagnosis is essential in reducing morbidity and mortality. The high mortality rate of gynecological cancers can mainly be attributed to ovarian cancer (OC). OC is commonly diagnosed at an advanced stage due to a lack of proper screening tools allowing early detection. Endometrial cancer (EC) on the contrary, is mostly diagnosed at an early stage and has, in general, better outcomes. The incidence of nonendometrioid EC has increased in the last decade, displaying a shared tumor biology with OC and consequently significantly worse outcome. New approaches allowing detection of gynecological cancers in an early stage are therefore desired. Recent studies on cancer biology have shown the relevance of altered glycosylation in the occurrence and progression of cancer. The aberrant expression of sialic acid, a specific carbohydrate terminating glycoproteins and glycolipids on the cell‐surface, is frequently correlated with malignancy. We aimed to determine the current understanding of sialic acid function in different gynecological cancers to identify the gaps in knowledge and its potential use for new diagnostic and therapeutic avenues. Therefore we performed a review on current literature focusing on studies where sialylation was linked to gynecological cancers. The identified studies showed elevated levels of sialic acid in serum, tissue and sialylated antigens in most patients with gynecological cancers, underlining its potential for diagnosis.

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ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling

Cited by 11 publications

References 42 publications

Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

Sialic acids in gynecological cancer development and progression: Impact on diagnosis and treatment

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