Stabilities of trivalent metal ion complexes of the tetraacetate derivatives of 12-, 13- and 14-membered tetraazamacrocycles

Long-term retention of gadolinium in the skin of rodents following the administration of gadolinium-based contrast agents

“…To assess the pharmacokinetic parameters of GBCAs, Omniscan, Magnevist, MultiHance and Gadovist were [8], b [9], c [9,10], d [2], e [11], f [12], g [13], h calculated from [14], i calculated from [15], j calculated from [16,17], k calculated from [18], l calculated from [19] injected once at a dose of 2.5 mmol/kg b.w. into the tail vein, and blood samples were taken from the cannulated carotid vein at various time-points p.i.…”

Radiolabeling and biological evaluation of DOTA-Ph-Al derivative conjugated to anti-EGFR antibody ior egf/r3 for targeted tumor imaging and therapy

“…111 In and therapeutic radionuclide like 90 Y, which does not bind non specifically to biological system, the only chelator known to form stable complexes is DOTA and its derivatives with excellent radiophysical properties have been well characterized. [14][15][16][17][18][19][20][21]29,31 The thermodynamic stability of bifunctional DOTA is not unusual but a convenient synthetic approach to produce readily available bifunctional DOTA to be conjugated to the protein molecule is highlighted in the present work. Linkage to the one of the carboxylate of the DOTA provided shorter synthetic route and the macrocyclic framework is well organized giving thermodynamic and kinetic stability.…”

“…Derivatives of DOTA constituted a promising class of chelating agents for radiotherapy because they form extremely stable and inert complexes with a wide variety of metal anion. [15][16][17][18][19][20] We have developed convenient route of synthesis based on DOTA-BA in which the coordination chemistry is well defined. 21 This paper presents the successful synthesis of a new derivative of DOTA with a single amino acid phenylalanine linker to facilitate fast clearance of radioactive drug from blood and reduce the radiation exposure to the normal tissue and its conjugation with anti EGFR antibody ior egf/r3.…”

68Ga-Labeled Radiopharmaceuticals for Positron Emission Tomography

“…Various 68 Ga-labeled agents have been developed using NOTA as the basic chelating agent, because of the high stability of the chelate formed; for example, the log K value of gallium-NOTA [47,48] has been reported to be 30.98, which is much higher than that of gallium-DOTA (21.33) [49]. DOTA has eight binding sites available for complexing with metals, but NOTA has only six, and thus, no free binding site remains after complexing NOTA with gallium, which requires all six binding sites.…”