This paper describes a systematic approach for the stability analysis of RF and microwave nonlinear circuits in the time-domain and that can be useful also for the verification of other nonlinearities, like intermodulation. Time-domain analysis is the most reliable approach for the evaluation of complex nonlinear phenomena but, in general, the transient behaviour of nonlinear circuits is difficult to verify at high frequencies, where distributed elements are common. The solution here addressed overcomes this limitation and it may be applied, without restrictions, also to monolithic microwave integrated circuits and EM-based designs. Examples of application to hybrid prototypes are provided, and the comparison between simulations and measurements illustrates the accuracy and reliability of the proposed approach.