This study investigates the impact of hot heat exchanger (HHX) inlet temperature on Sigma-thermic heat transfer fluid (STHF or STF) performance in a natural circulation loop. Various fluids, including STHF and STHF-based nanofluids, with volumetric concentrations ranging from 0.5% to 3%, are employed in the loop. The primary objective is to analyze the thermal performance of the loop under different conditions, focusing on temperature distribution, Nusselt number, friction factor, effectiveness, and mass flow rate. 3D numerical simulations are conducted, and the numerical model is validated against existing literature. The developed model incorporates considerations for viscous dissipation and axial conduction to predict the heat transfer potential of the loop. As the HHX inlet temperature increases, the mass flow rate rises. Notably, STHF/CuO nanofluids exhibit a more substantial enhancement than other nanofluids. At a 1 vol% concentration, the mass flow rate increases by 9.5%, 4%, and 2.7% for STHF/CuO, STHF/Al2O3, and hybrid nanofluids, respectively, compared to pure STHF. The study reveals significant improvements in mass flow rates and heat transfer efficiency with increasing HHX inlet temperatures, especially with STHF/CuO nanofluids. The total entropy generation reduction is notable, with percentages ranging from 2% to 18.5% for various nanofluids compared to pure STHF