Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide

Abstract

The aim of this study was to determine the compatibility and stability of morphine hydrochloride and hyoscine-N-butyl bromide combined in solution at three different concentrations and stored in polypropylene syringes at 4 degrees C and 25 degrees C over a period of 15 days. The doses assayed were 20, 60 and 120 mg/day for morphine hydrochloride and 40, 60 and 80 mg/day for hyoscine-N-butyl bromide. These dose ranges were chosen according to daily practice. At both temperatures, all mixtures can be considered as physically compatible since no evidence of incompatibility-that is precipitation, turbidity, colour change or opacity and gas production-were observed. After 15 days of storage, the percentages of hyoscine-N-butyl bromide remaining in the drug mixtures tested ranged between 96.07% and 92.23%. At the end of the study, the percentages of morphine hydrochloride remaining in the drug mixtures were 100% at both temperatures.

Stability studies of binary and ternary mixtures containing morphine, midazolam, levomepromazine and hyoscine butylbromide for parenteral administration

“…Barcia et al . considered the binary mixture morphine/hyoscine butylbromide (in similar doses to those in this study) to be stable for 15 days stored in propylene syringes at different temperatures and protected from direct light exposure.…”

“…The Mo‐Sco mixture has been extensively reported in the literature: Negro et al . and Barcia et al . used standard pharmacopeial methods to analyse each drug in intravenous mixtures, and Destro et al .…”

“…Unfortunately, there is a wide number of permutations in clinical practice regarding drug combination, doses, containers, storage conditions, etc., which make it difficult to extrapolate the results to other circumstances. In the literature there can be found many stability studies involving morphine and also studies involving binary mixtures combining morphine and hyoscine butylbromide, morphine and midazolam, midazolam and hyoscine butylbromide and morphine and levomepromazine and ternary mixtures combining morphine, midazolam and hyoscine butylbromide. Most of these studies used morphine sulphate, which is frequently used in the USA.…”

Binary Mixtures of Morphine and Furosemide: Compatibility and Stability at Different Concentrations

“…The physical compatibility and/or stability of several drugs in solution destined to subcutaneous infusion has been widely studied, [7][8][9][10][11] although in some studies only visual inspection of the samples was performed, providing information on the physical compatibility but not on the chemical stability of the drugs in the mixture. Moreover, studies have not yet been done regarding the combination of morphine and furosemide in solution in which the quantification of both drugs was performed by HPLC.…”

“…The drugs were chromatographed on a C 18 reverse phase column; the mobile phase was acetonitrile-water 40:60 (v/v); flow rate 1.5 mL/min. Morphine and furosemide concentrations were determined at 235 nm by interpolation from the calibration curves prepared at (0,1,2,3,7,8,9,10, 14, 15) days from the standards. Statgraphics centurion XVI program has been used to data treatment.…”