Stability and compatibility of reconstituted ertapenem with commonly used i.v. infusion and coinfusion solutions

Stability of ertapenem 100 mg/mL in polypropylene syringes stored at 25, 4, and −20 °C

“…In 0.9% sodium chloride injection, ertapenem 20 mg/mL is stable for up to 6 hours at room temperature after reconstitution and for up to 24 hours in the refrigerator, with the solution being administered within 4 hours after removal from the refrigerator. 1,15 Previous studies also identified a concentration-dependent stability between 10 and 20 mg/mL. 15 In the study described here, we found 100-mg/mL solutions of ertapenem stored in polypropylene syringes at 25 °C to be stable for just under 1 hour, with a range of 30-90 minutes.…”

“…1,15 Previous studies also identified a concentration-dependent stability between 10 and 20 mg/mL. 15 In the study described here, we found 100-mg/mL solutions of ertapenem stored in polypropylene syringes at 25 °C to be stable for just under 1 hour, with a range of 30-90 minutes.…”

Stability of doripenem in polyvinyl chloride bags and elastomeric pumps

“…[14][15][16] While this was partly true of studies performed at 4 °C in our study (in samples diluted with 5% dextrose injection), this was not the case at 25 °C in either freshly prepared or previously frozen doripenem solutions. While these findings are seemingly unique to doripenem, it is possible that at a higher concentration (i.e., 20 mg/mL), differences in stability could be found and would require further investigation before translating our results to a 2000-mg doripenem dose.…”

Microwave freeze-thaw technique of injectable drugs. A review from 1980 to 2014

“…MFTT was not applied. Contrariwise, Doripenem [70], ertapenem [71] and meropenem [72] (carbapenems, J01DH) do not support freezing. Imipenem was not tested but meet probably the same characteristics.…”