“…The stability of carboplatin in the presence of chloride ions, provided under perfusion conditions, has been largely studied (Lederer, M. and Leipzig-Pagani, 1998, Valière et al, 1996, Benaji et al, 1994, Prat et al, 1994, Hadfield et al, 1993, Van der Vigh, 1991. A degradation has been shown, with a probable production of cisplatin, that would increase the drug toxicity.…”