Stability and compatibility study of carboplatin with three portable infusion pump reservoirs

Rochard, E.; Barthes, D.; Courtois, P

doi:10.1016/0378-5173(94)90221-6

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…11,12 Accordingly, the final diluted infusion solutions are stable up to 8 h at 25 C. 11,12 Currently, there is an abundance of stability data on carboplatin solutions prepared in D5W. [13][14][15][16][17][18][19][20][21][22] Many of these studies have been reviewed elsewhere, 23 and a comprehensive review of the data is beyond the scope of this manuscript. In brief, the stability of carboplatin-D5W infusion solutions stored at room temperature ($25 C) ranges from 1 day to 30 days in various administration packages.…”

Section: Introductionmentioning

confidence: 99%

“…In brief, the stability of carboplatin-D5W infusion solutions stored at room temperature ($25 C) ranges from 1 day to 30 days in various administration packages. 13,[15][16][17]20,21 For example, 0.1 mg/mL and 1.0 mg/mL solutions prepared in D5W in glass containers and stored at 25 C in a water bath were stable up to one day, 15 whereas a 3.2 mg/mL solution stored in a glass bottle at 25 C was stable up to 28 days. 20 In polyvinyl chloride (PVC) bags at 25 C, the stability of various solutions of !0.5 mg/mL was within the range of 7-21 days.…”

Section: Introductionmentioning

confidence: 99%

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Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags

Myers

Zhang

Kawedia

et al. 2014

J Oncol Pharm Pract

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The extended physico-chemical stability of carboplatin prepared in sodium chloride reported herein permits advance preparation of these admixtures, facilitating pharmacy utility and operations. Since no antibacterial preservative is contained within these carboplatin solutions, we recommend storage, when prepared under specified aseptic conditions, no greater than 24 h at room temperature or three days under refrigeration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags

Myers

Zhang

Kawedia

et al. 2014

J Oncol Pharm Pract

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“…Currently, etoposide is administered via a 1-h infusion of a diluted solution, while carboplatin is administered using a disposable infusion device because stability data concerning the latter drug are already available in the literature [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

“…In the Department of Paediatrics at Gustave Roussy, a regimen combining etoposide and carboplatin (VP-Carbo) was designed for day hospital paediatrics (DHP) treatment of neuroblastomas or medulloblastomas in children. Currently, etoposide is administered via a 1-h infusion of a diluted solution, while carboplatin is administered using a disposable infusion device because stability data concerning the latter drug are already available in the literature [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

et al. 2014

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In a context of day hospital care of cancer patients, a protocol combining etoposide and carboplatin is used in paediatrics. Disposable infusion devices can be used to improve patient quality of life and to optimize nursing time. Stability data are available for carboplatin in these devices but not for etoposide. The aim of this study was to determine the stability of etoposide solutions in these devices by monitoring the changing etoposide concentration. To study the changing etoposide concentration, we investigated three different concentrations, each in two different solvents: sodium chloride (NaCl) 0.9 % and dextrose 5 %, in Intermate® disposable infusion devices. Quantitative analyses were performed by high-performance liquid chromatography coupled with ultraviolet (UV) detection on samples collected over a 24-h study period. The results showed that 100 mg/L etoposide solutions were stable for 24 h in NaCl 0.9 % and for 12 h in dextrose 5 %, whatever the temperature. The 400-mg/L solutions were stable for 24 h in both diluents, whatever the temperature, whereas the 600-mg/L solutions when diluted in NaCl 0.9 % and dextrose 5 % in water were stable for 8 and 6 h, respectively. We found that precipitation was the main phenomenon responsible for decreased etoposide concentrations. This study allowed us to conclude that etoposide solutions prepared in Intermate® infusion devices are stable for day hospital administration in paediatrics. It will also allow us to conduct a future clinical study that will focus on the medico-economic feasibility of this protocol and on the evaluation of patient and nurse satisfaction.

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Interstitial continuous infusion therapy in a malignant glioma model in rats

et al. 2009

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Stability and compatibility study of carboplatin with three portable infusion pump reservoirs

Cited by 8 publications

References 4 publications

Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags

Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags

Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices

Interstitial continuous infusion therapy in a malignant glioma model in rats

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