In this paper, the dynamics of a generalized two-neuron model with self-connections and distributed delays are investigated, together with the stability of the equilibrium. In particular, the conditions under which the Hopf bifurcation occurs at the equilibrium are obtained for the weak kernel. This means that a family of periodic solutions bifurcates from the equilibrium when the bifurcation parameter exceeds a critical value. Explicit algorithms for determining the stability of the bifurcating periodic solutions and the direction of the Hopf bifurcation are derived by using the theory of normal form and center manifold [20]. Some numerical simulations are given to illustrate the effectiveness of the results found. The obtained results are new and they complement previously known results.