Improving environmental sustainability involves measuring indices that show responses to different production processes and management types. Suspended sediment concentration (SSC) in water bodies is a parameter of great importance, as it is related to watercourse morphology, land use and occupation in river basins, and sediment transport and accumulation. Although already established, the methods used for acquiring such data in the field are costly. This hinders extrapolations along water bodies and reservoirs. Remote sensing is a feasible alternative to remedy these obstacles, as changes in suspended sediment concentrations are detectable by satellite images. Therefore, satellite image reflectance can be used to estimate SSC spatially and temporally. We used Sentinel-2 A and B imagery to estimate SSC for the Teles Pires River in Brazil’s Amazon. Sensor images used were matched to the same days as field sampling. Google Earth Engine (GEE), a tool that allows agility and flexibility, was used for data processing. Access to several data sources and processing robustness show that GEE can accurately estimate water quality parameters via remote sensing. The best SSC estimator was the reflectance of the B4 band corresponding to the red range of the visible spectrum, with the exponential model showing the best fit and accuracy.