“…Neuronal firing is the outcome of many interacting non-linear membrane properties and ionic mechanisms, and bifurcation analysis provides a means to study and quantify the effect(s) each membrane property has on cell firing. As XPPAUT does not have tools to facilitate the development of high-fidelity neuronal models with detailed anatomy and multiple ion channels, bifurcation analysis has been traditionally conducted on reduced neuronal models of a single compartment with only a few ion channels ( White et al, 1995 ; Wang et al, 2019 , 2021 ; Xing et al, 2022 ). While bifurcation analysis of reduced neuronal models has been instrumental in shaping our understanding of the neuronal non-linear dynamics underlying membrane oscillations and cell firing under normal ( Jalics et al, 2010 ; Zhou et al, 2018 ), pathological ( Glass and Mackey, 1979 ; Kaper et al, 2013 ), and pharmacological ( V-Ghaffari et al, 2017 ) conditions, extending this analysis to higher-fidelity models with multiple compartments and dendritic channels, which mediate many non-linear firing behaviors in MNs ( Hounsgaard and Kiehn, 1993 ; Li and Bennett, 2007 ; Carlin et al, 2009 ) has been limited.…”