Stability and robustness of blood variables in an antidoping context

Robinson, Neil; Sottas, Pierre-Edouard; Pottgießer, Torben; Schumacher, Y. O.; Saugy, Martial

doi:10.1111/j.1751-553x.2010.01256.x

Cited by 35 publications

(41 citation statements)

References 26 publications

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“…Most recently, Robinson et al . reported a more comprehensive data set than their initial study but again concluded that reticulocytes were stable through 72 h at 4 °C when measured on a Sysmex XT‐2000i.…”

Section: Discussionmentioning

confidence: 96%

Stability of athlete passport parameters during extended storage

Ashenden

Clarke²,

Sharpe

et al. 2012

Int J Lab Hematology

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Section: Discussionmentioning

confidence: 96%

Stability of athlete passport parameters during extended storage

Ashenden

Clarke²,

Sharpe

et al. 2012

Int J Lab Hematology

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show abstract

“…Firstly, since the OFF-score, a parameter used to calculate the probability of blood doping in athletes, depends on Hb concentration and Ret count (Sottas et al, 2010; Robinson et al, 2011; which remained stable), WBC may reduce the result of this score and, thus, cannot be considered a performance enhancing practice. On the other hand, the use of WBC to mask illicit practices is unjustified because the potential decrease in Hb is too small and the change itself is short-lasting and/or temporary (Lombardi et al, 2013a).…”

Section: Hematologymentioning

confidence: 99%

Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature

2017

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Nowadays, whole-body cryotherapy is a medical physical treatment widely used in sports medicine. Recovery from injuries (e.g., trauma, overuse) and after-season recovery are the main purposes for application. However, the most recent studies confirmed the anti-inflammatory, anti-analgesic, and anti-oxidant effects of this therapy by highlighting the underlying physiological responses. In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the deleterious effects of exercise-induced inflammation and soreness. Novel findings have stressed the importance of fat mass on cooling effectiveness and of the starting fitness level on the final result. Exposure to the cryotherapy somehow mimics exercise, since it affects myokines expression in an exercise-like fashion, thus opening another possible window on the therapeutic strategies for metabolic diseases such as obesity and type 2 diabetes. From a biochemical point of view, whole-body cryotherapy not always induces appreciable modifications, but the final clinical output (in terms of pain, soreness, stress, and post-exercise recovery) is very often improved compared to either the starting condition or the untreated matched group. Also, the number and the frequency of sessions that should be applied in order to obtain the best therapeutic results have been deeply investigated in the last years. In this article, we reviewed the most recent literature, from 2010 until present, in order to give the most updated insight into this therapeutic strategy, whose rapidly increasing use is not always based on scientific assumptions and safety standards.

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“…[29,30] If such storage conditions have not been respected or are not documented, careful scrutiny of the red cell indices (e.g.…”

Section: Collectionmentioning

confidence: 99%

Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport

Schumacher

Saugy²,

Pottgießer

et al. 2012

Drug Testing and Analysis

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The increase of the body's capacity to transport oxygen is a prime target for doping athletes in all endurance sports. For this pupose, blood transfusions or erythropoiesis stimulating agents (ESA), such as erythropoietin, NESP, and CERA are used. As direct detection of such manipulations is difficult, biomarkers that are connected to the haematopoietic system (haemoglobin concentration, reticulocytes) are monitored over time (Athlete Biological Passport (ABP)) and analyzed using mathematical models to identify patterns suspicious of doping. With this information, athletes can either be sanctioned directly based on their profile or targeted with conventional doping tests. Key issues for the appropriate use of the ABP are correct targeting and use of all available information (e.g. whereabouts, cross sectional population data) in a forensic manner. Future developments of the passport include the correction of all concentration‐based variables for shifts in plasma volume, which might considerably increase sensitivity. New passport markers from the genomic, proteomic, and metabolomic level might add further information, but need to be validated before integration into the passport procedure. A first assessment of blood data of federations that have implemented the passport show encouraging signs of a decreased blood‐doping prevalence in their athletes, which adds scientific credibility to this innovative concept in the fight against ESA‐ and blood doping. Copyright © 2012 John Wiley & Sons, Ltd.

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Stability and robustness of blood variables in an antidoping context

Abstract: In conclusion, our data clearly demonstrate that as long as the World Anti-Doping Agency's guidelines are followed rigorously, all blood results reach the quality level required in the antidoping context.

Cited by 35 publications

References 26 publications

Stability of athlete passport parameters during extended storage

Stability of athlete passport parameters during extended storage

Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature

Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport

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