2014
DOI: 10.1126/science.aaa1543
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Stability at the surface

Abstract: Aging guards invite a jailbreak. With aging, increased stress, DNA damage, and telomere shortening weaken the multiple systems that keep retrotransposons in check. Aged cells lose repressive heterochromatin, SIRT6 relocalizes away from L1 promoters, and autophagy becomes less efficient. Other defense pathways (see box) may also lose their effectiveness. The consequent unleashing of L1 elements could lead to profound somatic damage, driving age-associated cell and tissue dysfunction.Published by AAAS registered… Show more

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Cited by 6 publications
(4 citation statements)
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“…Whereas there has been remarkable experimental and theoretical progress in our knowledge about structure and properties of two-dimensional metal-oxide surfaces and interfaces 65 , quantitative determination and understanding of the atomic structure of metal-oxide surfaces rolled into nanotubes lags behind. Here, the structure of two new members of the family of metal-oxide nanotubes, specifically single-walled methylated aluminosilicate and aluminogermanate nanotubes, has been determined at the atomic level from WAXS experiments, which is a first contribution to bridging the gap.…”
Section: Discussionmentioning
confidence: 99%
“…Whereas there has been remarkable experimental and theoretical progress in our knowledge about structure and properties of two-dimensional metal-oxide surfaces and interfaces 65 , quantitative determination and understanding of the atomic structure of metal-oxide surfaces rolled into nanotubes lags behind. Here, the structure of two new members of the family of metal-oxide nanotubes, specifically single-walled methylated aluminosilicate and aluminogermanate nanotubes, has been determined at the atomic level from WAXS experiments, which is a first contribution to bridging the gap.…”
Section: Discussionmentioning
confidence: 99%
“…Surface structure can fundamentally affect the physical and chemical properties of metal oxides, which have promising applications in the fields of catalysis, environment, and electronic devices. It is therefore of crucial importance to explore the atomic structure of oxide surfaces and fully understand the structure–property relationship, especially for the minority surfaces, which are expected to possess superior properties. Taking titanium dioxide (TiO 2 ), the most studied metal oxide system in surface science, as an example, most of its functional applications generally rely on the interaction between molecules/ions and its surface facets and defects. When exposed with different facets, TiO 2 nanocrystals show distinctly different performances in photocatalysis, dye-sensitized solar cell (DSSC), lithium battery, and water splitting for hydrogen . Some minority facets even exhibit new physical or chemical phenomena; , for instance, the dissociative adsorption of water can occur on anatase minority {001} surface but not on its thermodynamically stable {101} surface .…”
mentioning
confidence: 99%
“…Notably, since oxygen migration induces unclear phenomena like the formation of the intermediate orthorhombic phase and the wake-up behavior of ferroelectricity, the stabilization of ferroelectric HfO 2 in terms of oxygen migration is a decisive concern for the fundamental understanding. Also, as the device structures scaled down, device functionality increasingly depends on the nanoscale structure of device components, particularly on the atomic arrangements at interfaces between different materials. Considering the technology relevant to ferroelectric HfO 2 , the crystallographic control and epitaxial stabilization of a single-oriented ferroelectric HfO 2 thin film itself are of great interest for the deep understanding of the nature of ferroelectricity in HfO 2 . Here, we stabilized a single-crystalline ferroelectric HfO 2 film with various growth directions through oxygen ion movement between the HfO 2 layer and the oxide electrode layer.…”
Section: Introductionmentioning
confidence: 99%