In this paper, we show that an infinite network of input-to-state stable (ISS) subsystems, admitting ISS Lyapunov functions, itself admits an ISS Lyapunov function, provided that the couplings of the subsystems are sufficiently weak. The strength of the couplings is described in terms of the properties of an infinite-dimensional nonlinear positive operator, built from the interconnection gains. If this operator satisfies the so-called robust small-gain condition and induces a uniformly globally asymptotically stable discrete-time system, a Lyapunov function for the infinite network can be constructed. In the case of linear interconnection gains, these conditions are equivalent to a spectral small-gain condition, expressed in terms of a generalized spectral radius.