Stability enhancement of lycopene in Citrullus lanatus extract via nanostructured lipid carriers

Abstract

Lycopene is one of naturally occurring carotenoids in plants including watermelon (Citrullus lanatus). Heat, light, and oxygen effect on lycopene isomerization and degradation. Nanostructured lipid carriers (NLCs) are drug delivery system which can enhance the stability of active compound. Therefore, this study aimed to develop watermelon extract loaded in NLCs for lycopene stability improvement. The NLCs were prepared using a hot homogenization technique. Cocoa butter was used as solid lipid. Grape seed oil was used as liquid lipid. Span® 80 and Plantasens® HE20 were used as an emulsifier. The selected unloaded NLCs contained solid lipid to liquid lipid at the ratio of 3:1 and 10% (w/w) of total lipid. The particle size of watermelon extract‐loaded NLCs (WH‐loaded NLCs) was 130.17 ± 0.72 nm with low PDI and high zeta potential. It also presented high entrapment efficiency. For stability study, the WH‐NLC3 could enhance stability and maintain lycopene content after stability test. It exhibited the highest values of lycopene content (83.26 ± 2.30%) when stored at 4°C. It also possessed a prolonged release pattern over 48 hr. Therefore, the NLCs could improve stability and release profile of lycopene from watermelon extract.

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

“…Herein, a high IMT entrapment efficiency was observed in the developed formulation (F16-IMT) (Table 7). This provides clear evidence for the greater drug encapsulation tendency of NLCSs [47][48][49][50]. In addition, the results demonstrate that the composition of the developed formulation is suitable for the delivery of IMT.…”

Natural Stabilizers and Nanostructured Lipid Carrier Entrapment for Photosensitive Compounds, Curcumin and Capsaicin

“…The major components of NLCs comprise solid lipid (glyceryl distearate), liquid lipids (isopropyl myristate, sunflower oil, and olive oil), emulsifiers (polysorbate 80 and sorbitan oleate), and distilled water [39,40]. The compositions of NLCs were varied to determine the most appropriate formulation (small droplet size, well-dispersed particles, and good stability), as shown in Table 3 [41]. Characterization and Stability of NLCs…”

Formulation and Characteristics of Nanostuctured Lipid Carrier (NLC) Red Palm Oil (RPO) Prepared by High-Pressure Homogenization and Its Applications in Orange Juice

“…This is probably caused by the use of liquid lipids and homogenization process using HPH which can break down RPO-NLC particles into smaller ones. Thus causing the crystal structure of NLC particles to be imperfect and results encapsulation for components micronutrient compounds to be maximized (Sirikhet et al, 2021).…”