Stability-indicating densitometric determination of some antidiabetic drugs in dosage forms, using TLC

Kousy, N.M El

doi:10.1007/bf01242191

Cited by 18 publications

(8 citation statements)

References 13 publications

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“…Recovery of glipizide in its pharmaceutical formulation (Minidiab tablets), based on the average of four replicate measurements is reported in Table 2. The results obtained were statistically compared with those obtained by a reported TLC method [7]. Values of F-calculated, F-theoretical, t-calculated and t-theoretical are also included in Table 2.…”

Section: Analysis Of Minidiab Tabletsmentioning

confidence: 98%

“…Glipizide has been determined by several techniques including high-performance liquid chromatography [2][3][4][5][6], thin layer chromatography [7], liquid chromatography [8,9] capillary electrophoresis [10], radioimmunoassay [11] and non-aqueous titrimetry [12]. Glipizide was determined also in formulation based on its electrochemical oxidation at a carbon * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…Assay of glipizide in its pharmaceutical formulation (Minidiab ® tablets) by the proposed SWAdCS voltammetric procedure and a reported TLC method[7] Claimed (mg/tablet) 5 Recovery (%R ± R.S.D.) by the proposed method (calibration curve method)102.84 ± 0.86Recovery (%R ± R.S.D.)…”

mentioning

confidence: 99%

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Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Ghoneim

El-Attar

Hammam

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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Section: Analysis Of Minidiab Tabletsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Ghoneim

El-Attar

Hammam

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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“…[2][3][4][5][6][7][8][9] But there is only one method [10] for the simultaneous estimation of these two combinations (I and II) in which an ion pair liquid chromatographic technique has been used. [2][3][4][5][6][7][8][9] But there is only one method [10] for the simultaneous estimation of these two combinations (I and II) in which an ion pair liquid chromatographic technique has been used.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Metformin in Its Multicomponent Dosage Forms with Glipizide and Gliclazide Using Micellar Liquid Chromatography

Kolte

Raut

Deo

et al. 2003

Journal of Liquid Chromatography & Related Technologies

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An HPLC procedure for the simultaneous determination of metformin in combination with glipizide and gliclazide in pharmaceutical preparations is described. A Zorbax XDB C 18 15 cm analytical column and UV detection at wavelength 226 nm were used. In this study, various mobile phase variables were studied to determine the effects that each had on metformin, glipizide, and gliclazide. The reproducibilities in combination I for metformin and glipizide were 1.39%, 1.30%, and in combination II for metformin and gliclazide were 1.28%, 1.75%, respectively.The determinations of glipizide, metformin (combination I), and gliclazide, metformin (combination II) gave recoveries with respect to the values declared by the manufacturers for glipizide and metformin (combination-I) in the range 96.1-103.4%, 95.0-100.0% using peak areas, and 96.4-103.6%, 97.3-102.5% using peak heights, respectively. The recoveries for the gliclazide and metformin (combination II) were in the range 94.7-100.8%, 96.2-101.2% using peak areas, and 94.3-101.5%, 97.8-102.5% using peak heights, respectively.

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“…European Pharmacopeia [20] describes a titrimetric assay in which drug in dimethyl formamide is titrated with lithium methoxide using quinaldine red as indicator. Methods based on numerous other techniques have been suggested for the determination of GPZ in pharmaceuticals including, uv-spectrophotometry [21][22][23][24], UPLC [25,26], TLC [27,28], HPTLC [29] and voltammetry [30].…”

Section: Glipizidementioning

confidence: 99%

Rapid and Reliable Determination of Glipizide in Pharmaceutical Samples by HPLC and Its Degradation Study

Basavaiah¹

2017

Austin J Anal Pharm Chem

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A simple, specific and rapid high-performance liquid chromatographic (HPLC) method for the determination of glipizide (GPZ) in pharmaceutical sample is described. Reversed phase chromatography was performed on an Inertsil ODS 3V (150 × 4.6mm; 5µm particle size) column with an isocratic mobile phase consisting of 10mM potassium dihydrogen phosphate (pH 3.9) and methanol (60:40 v/v). The effluent was monitored on a uv detector at 220nm and the column temperature was maintained at 35ᴼC. Linear response (r=0.9999) was observed over the range, 1-450µgmL -1 ; and the limits of detection (LOD) and quantification (LOQ) were calculated to be 0.03 and 0.09 µgmL -1 , respectively. Both intra-day and inter-day precisions at three tested concentrations were excellent, with %RSD values of <1% and the accuracy was better than 1.5% (RE). The method was also validated for robustness, ruggedness and selectivity and the results were satisfactory. The method was applied to the determination of GPZ in tablets and the results agreed well with the label claim and those obtained by European Pharmacopeial method. Entire assay was complete in less than 10min. As part of degradation study, the drug was subjected to acid-, base-, peroxide-, heat-, and light-induced stress conditions, and the drug was found to be susceptible to degradation under oxidation, and inert to other conditions.

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Stability-indicating densitometric determination of some antidiabetic drugs in dosage forms, using TLC

Cited by 18 publications

References 13 publications

Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation

Simultaneous Determination of Metformin in Its Multicomponent Dosage Forms with Glipizide and Gliclazide Using Micellar Liquid Chromatography

Rapid and Reliable Determination of Glipizide in Pharmaceutical Samples by HPLC and Its Degradation Study

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