Stability-indicating HPLC Method for Determination of Naproxen in an Extemporaneous Suspension

Songnaka, Nuttapon; Sawatdee, Somchai; Atipairin, Apichart

doi:10.5958/0974-360x.2018.00793.x

Cited by 2 publications

(5 citation statements)

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“…Therefore, it has been widely used to manage chronic and acute pain, swelling, fever and inflammation. In addition, it is used to treat inflammatory rheumatic and other rheumatoid arthritis diseases (Camilo and Foley, 2021;Muneer et al, 2017;Sondnara et al, 2018). Because, naproxen is rapidly absorbed from the gastrointestinal tract (Yuan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Tavşan Plazmasında Naproksenin GC-MS Yöntemi ile Analizi

Yılmaz

2022

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Naproksen günümüzde en çok kullanılan ilaçlardan biridir. Bu nedenle, naproksen tayini için yeni ve basit yöntemlerin geliştirilmesi önemlidir. Bu çalışmanın amacı tavşan plazmasında naproksenin analizi için bir gaz kromatografisi-kütle spektrometri yöntem geliştirmek ve farmakokinetik çalışmaya uygulamaktır. Tavşan kan örnekleri sıvı-sıvı ekstraksiyon yöntemi ile hazırlanmıştır. Naproksenin ayırımı HP-5 MS kolon ile yapılmıştır. Yöntemin kalibrasyon eğrisi 0.1 ve 5.0 μg mL-1 arasında çizildi. Tavşan plazmasında naproksenin kesinlik sonuçları %4.17’den küçüktü ve doğruluk sonuçları %2.18’den daha iyiydi. Yöntemin tavşan plazmasındaki tüm örnekler için geri kazanım değerleri >%94.2’tür. Ayrıca, tavşanlarda naproksenin farmakokinetiğini incelemek için valide edilen yöntem uygulanmıştır. Maksimum naproksen plazma konsantrasyonu 42.1±4.243 μg mL-1 idi. Naproksenin maksimum konsantrasyona ulaşma süresi ve eğrinin altındaki alan (AUC0-16 h) sırasıyla 1.50±0.196 h ve 566.3±41.72 μg mL-1 idi.

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Section: Introductionmentioning

confidence: 99%

Tavşan Plazmasında Naproksenin GC-MS Yöntemi ile Analizi

Yılmaz

2022

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…A variety of stability indicating chromatographic procedures under different stress conditions such as hydrolysis, thermal, photolytic degradation, and oxidative stress were applied for the analysis of naproxen in pharmaceutical formulations and its impurities [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Songnaka et al [8] developed a new stability-indicating HPLC procedure for the analysis of naproxen in an extemporaneous suspension. The decomposition of naproxen sample was stated in the acid-catalyzed hydrolysis (0.1N HCl).…”

Section: Introductionmentioning

confidence: 99%

“…The decomposition of naproxen sample was stated in the acid-catalyzed hydrolysis (0.1N HCl). However, the drug remained intact in the basic (0.1N NaOH) and neutral (H 2 O) hydrolysis [8].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous analytical methods like spectrophotometry [19,[26][27][28], titration [29], microextraction [30], voltammetry [31][32][33] chromatographic technologies in combination with various detection systems (HPLC, UPLC, GC, TLC) [5][6][7][8][9][10][11][12][13][14]18,20,28,32,[34][35][36][37][38][39][40][41][42][43][44] and also electrophoresis [45,46] were utilized for the naproxen determination in different matrix in sampling biological materials (e.g., urine, plasma), water samples (wastewater), and also in simple and complex drug formulations.…”

Section: Introductionmentioning

confidence: 99%

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Rapid TLC with Densitometry for Evaluation of Naproxen Stability

2020

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The purpose of the work was to develop such chromatographic conditions that allowed to separate as many naproxen degradation products as possible. In order to follow this process, thin-layer chromatography (TLC) coupled with densitometry and spectrodensitometry was used. A forced degradation study was performed using an ethanolic solution of naproxen spotted on silica gel plates, existing in the form of an aqueous solution at various pH values, and as solution prepared in saline and in hydrogen peroxide. Degradative effect of UV light on naproxen was watched in the context of naproxen spotted on plates precoated with silica gel and exposed to UV light, and also for its solution treated with UV light. However, the solution of naproxen prepared in water at pH ≈ 2.60 undergoes the largest changes as the results of its exposure to UV light during 10 h. Stressed samples of naproxen were analyzed by using a new and well validated TLC procedure including toluene (TOL)—acetone (ACE)—chloroform (CHL) (2:5:12, v/v/v) as mobile phase A and glacial acetic acid (AcOH)—n-hexane (Hex)—acetone (ACE)-(0.10:10:10, v/v/v) as mobile phase B. As the newly developed TLC-densitometric method can effectively separate the substances about pharmaceutical significance from products of its degradation, which are formed as a result of stress studies, is considered to be a good alternative and important tool in routine quality control and stability testing of naproxen in pharmaceutical formulations. These results indicate that proposed TLC-densitometric method is cost-effective, rapid, specific, accurate, and precise. This TLC procedure is comparable to HPLC and UPLC method in terms of detection the number of degradation products of naproxen. In addition, it realizes the criterion of linearity. A major advantage and novelty of proposed method is its low cost and ability to analyze examined drug and all degradation products simultaneously, including those which can be observed under intensive UV radiation exposure of naproxen solution which are not described by previous HPTLC studies available in the literature.

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Stability-indicating HPLC Method for Determination of Naproxen in an Extemporaneous Suspension

Cited by 2 publications

References 0 publications

Tavşan Plazmasında Naproksenin GC-MS Yöntemi ile Analizi

Tavşan Plazmasında Naproksenin GC-MS Yöntemi ile Analizi

Rapid TLC with Densitometry for Evaluation of Naproxen Stability

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