Stability of a biodegradable microcarrier surface: physically adsorbed versus chemically linked shells

Abstract

Microcarriers' shell stability was studied with competitive surfactants or with proteins contained in the MSCs culture medium.

Doxorubicin Intracellular Release Via External UV Irradiation of Dextran-g-poly(o-nitrobenzyl acrylate) Photosensitive Nanoparticles

“…This click chemistry leads to produce a covalent linkage between Dex and PNBA parts via triazole rings producing Dex- g -PNBA copolymers at the interface (Figure ). Interestingly, while a quantitative surface desorption from the “unclicked” NPs was observed in the presence of a competitive surfactant, the desorption was significantly reduced (around 80% decrease) in case of “clicked” NPs due to this core/shell covalent bonding. ,, Such improved colloidal stability, thanks to covalent bonding, is already reported in many systems, for example, for the complexation of polyelectrolytes of opposite charge …”

“…Interestingly, while a quantitative surface desorption from the "unclicked" NPs was observed in the presence of a competitive surfactant, the desorption was significantly reduced (around 80% decrease) in case of "clicked" NPs due to this core/shell covalent bonding. 23,25,53 Such improved colloidal stability, thanks to covalent bonding, is already reported in many systems, for example, for the complexation of polyelectrolytes of opposite charge. 54 In the present study, "clicked" NPs were then formulated and compared with "unclicked" NPs (Table 1, run 3).…”

Dextran-Coated Latex Nanoparticles via Photo-RAFT Mediated Polymerization Induced Self-Assembly

“…Native polysaccharides [ 10 ] or hydrophobically modified polysaccharides [ 11 , 12 , 13 ] have already been used to sterically stabilize monomer droplets during emulsion or mini-emulsion polymerization. However, the main limitation of this strategy is the potential desorption of polysaccharides in a harsh medium [ 14 , 15 , 16 ]. To prevent such phenomenon, polysaccharides were covalently linked to the hydrophobic core in situ using click chemistry [ 15 ] or by using pre-synthesized polysaccharide-based amphiphilic copolymers that form nanoparticles in water [ 17 , 18 , 19 , 20 ].…”

Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect

“…[1][2][3][4][5][6] For many decades, the self-assembly of AGPs in water has been induced via "conventional assembly processes", 6,7 including nanoprecipitation, [8][9][10][11][12][13][14] and emulsion-solvent evaporation. [15][16][17][18][19][20][21][22] Namely, in these pathways, pre-synthesized amphiphilic copolymers are initially dissolved in a common organic solvent for both blocks followed by a gradual addition of water, a selective solvent for one of the blocks, to induce the formation of nanoobjects. Although such processes are relatively simple to perform at the laboratory scale, their industrial transposition is limited due to the low solids concentration (typically <1 %wt) prepared and the multiple processing and purification steps required.…”