Stability of a half-sandwich Os(<scp>ii</scp>) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A

Masaryk, Lukáš; Muthná, Darina; Halaš, Petr; Zoufalý, Pavel; Peterová, E; Havelek, Radim; Drahoš, Bohuslav; Milde, David; Mrkvicová, Alena; Štarha, Pavel

doi:10.1039/d2dt01085b

Cited by 2 publications

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“…A similar strategy was applied for osmium(II) complex [Os(η 6 -pcym)Cl(L ind )]PF 6 ( Os ind ) containing the 2-(1,3,4-thiadiazol-2-yl)pyridine-based ligand bearing the cyclooxygenase inhibitor indomethacin (ind) [ 92 ]. This time, the bioactive substituent (i.e., ind) was bound to the carrier chelating ligand through the amide bond, which was cleaved exclusively in the presence of enzyme carboxypeptidase A (from bovine pancreases).…”

Section: Transition Metal Complexes For Cancer Therapymentioning

confidence: 99%

Chemistry towards Biology—Instruct: Snapshot

Hricovíni

Owens

Bąk

et al. 2022

IJMS

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The knowledge of interactions between different molecules is undoubtedly the driving force of all contemporary biomedical and biological sciences. Chemical biology/biological chemistry has become an important multidisciplinary bridge connecting the perspectives of chemistry and biology to the study of small molecules/peptidomimetics and their interactions in biological systems. Advances in structural biology research, in particular linking atomic structure to molecular properties and cellular context, are essential for the sophisticated design of new medicines that exhibit a high degree of druggability and very importantly, druglikeness. The authors of this contribution are outstanding scientists in the field who provided a brief overview of their work, which is arranged from in silico investigation through the characterization of interactions of compounds with biomolecules to bioactive materials.

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Section: Transition Metal Complexes For Cancer Therapymentioning

confidence: 99%