Stability of Amphotericin B in Four Concentrations of Dextrose Injection

Wiest, Donald B.; Maish, William; Garner, Sandra S.; El-Chaar, Gladys M.

doi:10.1093/ajhp/48.11.2430

Cited by 2 publications

(1 citation statement)

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“…Wiest et al [232] documented the stability of amphotericin B (100 lg/mL) in four different concentrations of dextrose injection (5%, 10%, 15%, and 20%), when stored for up to 24 h at 15-25°C and protected from light. This study raised an important question regarding the administration of the drug in dextrose solutions, with concentrations greater than 5%, which would minimize nutritional deficits and glucose instability in neonates.…”

Section: Stabilitymentioning

confidence: 99%

Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections

Cavassin

Baú-Carneiro²,

Vilas-Boas³

et al. 2021

Infect Dis Ther

197

123

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Introduced in the late 1950s, polyenes represent the oldest family of antifungal drugs. The discovery of amphotericin B and its therapeutic uses is considered one of the most important scientific milestones of the twentieth century . Despite its toxic potential, it remains useful in the treatment of invasive fungal diseases owing to its broad spectrum of activity, low resistance rate, and excellent clinical and pharmacological action. The well-reported and defined toxicity of the conventional drug has meant that much attention has been paid to the development of new products that could minimize this effect. As a result, lipid-based formulations of amphotericin B have emerged and, even keeping the active principle in common, present distinct characteristics that may influence therapeutic results. This study presents an overview of the pharmacological properties of the different formulations for systemic use of amphotericin B available for the treatment of invasive fungal infections, highlighting the characteristics related to their chemical, pharmacokinetic structures, drug–target interactions, stability, and others, and points out the most relevant aspects for clinical practice.

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Section: Stabilitymentioning

confidence: 99%

Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections

Cavassin

Baú-Carneiro²,

Vilas-Boas³

et al. 2021

Infect Dis Ther

197

123

View full text Add to dashboard Cite

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Role of Amphotericin B in the Treatment of Mucormycosis

Sachdeva,

Targhotra,

Kanwar Chauhan

et al. 2024

CPD

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Background:: Regardless of the most recent inclusion of mold-active agents (isavuconazole and posaconazole) to antifungal agents against mucormycosis, in conjunction with amphotericin B (AMB) items, numerous uncertainties still exist regarding the treatment of this rare infection. The order Mucorales contains a variety of fungi that cause the serious but uncommon fungal illness known as mucormycosis. The moulds are prevalent in nature and typically do not pose significant risks to people. Immunocompromised people are affected by it. Objective:: This article's primary goal is to highlight the integral role that AMB plays in this condition. Methods: Sinusitis (including pansinusitis, rhino-orbital, or rhino-cerebral sinusitis) is one of the many signs and symptoms of mucormycosis. The National Center for Biotechnology Information (NCBI) produces a variety of online information resources for review articles on the topic-based mucormycosis, AMB, diagnosis of mucormycosis and the PubMed® database of citations and abstracts published in life science journals. These resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov. Results:: The article provides a summary of the pharmacological attributes of the various AMB compositions accessible for systemic use. Conclusion:: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability, and other features, and illustrates their most useful characteristics for clinical application.

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Stability of Amphotericin B in Four Concentrations of Dextrose Injection

Cited by 2 publications

References 0 publications

Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections

Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections

Role of Amphotericin B in the Treatment of Mucormycosis

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