Abstract:Microbial cells need to adapt to changing environmental conditions to survive. There is an evolutionary advantage to grow fast; this requires high metabolic rates, and an efficient allocation of enzymatic resources. Here we study a general control theory called qORAC, developed previously, which allows cells to adaptively control their enzyme allocations to achieve maximal steady state flux. The control is robust to perturbations in the environment, but those perturbations themselves do not feature in the cont… Show more
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