Stability of Antibacterial Preservatives in Parenteral Solutions III

Lachman, Leon; Weinstein, S.; Urbányi, Tibor; Ebersold, E.; Cooper, J.

doi:10.1002/jps.2600520311

Cited by 4 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…70% in the upright and inverted position after 30 days of storage. In their study, the author discussed the observed effects in the context of a "contribution of rubber extractives and preservative degradation products towards enhanced antimicrobial activity" [134]. In a different study, they were able to identify the preservative-induced extractables by their UV absorbance [135].…”

Section: Chlorobutanolmentioning

confidence: 99%

“…Last, the extractables of butyl rubber could be identified as its primary accelerator (substituted carbamic acid) and its secondary accelerator (thiazole type) [135]. Thus, the apparently higher chlorobutanol concentration detected by the microbiological assay relative to the chemical method could be attributed to the presence of extractables which contributed to the increased antimicrobial activity of the solution [134,135]. Furthermore, Friesen & Plein (1971) reported that chlorobutanol was incompatible with polyethylene containers, resulting in a decreased antimicrobial efficacy compared to a glass control.…”

Section: Chlorobutanolmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview

et al. 2023

View full text Add to dashboard Cite

Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with the active pharmaceutical ingredient in addition to its preservation function. Thus, this review describes the current status of the use of antimicrobial preservatives in biologic formulations considering (i) appropriate preservatives for protein and peptide formulations, (ii) their physico-chemical properties, (iii) their in-/compatibilities with other excipients or packaging material, and (iv) their interactions with the biological compound. Further, (v) we present an overview of licensed protein and peptide formulations.

show abstract

Section: Chlorobutanolmentioning

confidence: 99%