Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (Stab Study)

Abstract

Antibiotics premixed in icodextrin PD-bags have varying stabilities with stability generally least at 37°C and best at 4(o)C, permitting storage for 14 days when refrigerated and prewarming to body temperature prior to administration. Further research confirming the sterility of these antibiotic-containing bags is recommended.

Stability of Ceftazidime and Heparin in Four Different Types of Peritoneal Dialysis Solutions

“…The physico-chemical stability of ceftazidime in the absence of heparin in various types of PD solutions has been reported before (11,13,24,28). However, the results obtained in the current study after storing a ceftazidime-PD admixture at 4°C and 25°C cannot be compared with the results reported by previous studies due to the difference in methodological approach.…”

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

“…Clinicians should remain alert for new studies in this area. In general, icodextrin-based PD solutions are compatible with vancomycin, cefazolin, ceftazidime, and gentamicin ( 329 , 333 , 334 ). When premixed in icodextrin solution, these antibiotics are least stable at 37°C and most stable at 4°C, permitting storage for 14 days when refrigerated and pre-warming to body temperature prior to administration ( 334 ).…”

Variation in Peritoneal Dialysis–Related Peritonitis Outcomes in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)

“…Icodextrin is compatible with the commonly used intraperitoneal antibiotics, including cefazoline, ceftazidime, vancomycin, and gentamicin. 31,32 The impact of icodextrin use on peritonitis outcomes remains uncertain. In a randomized controlled trial among 53 adult CAPD patients, no significant differences were observed in terms of peritonitis cure or 120-day mortality between groups treated with icodextrin and treated with glucose-based PD solutions.…”