Stability of doxorubicin combined with RadioselectanR, a contrast agent, for chemoembolization

Abstract

Doxorubicin combined with Radioselectan stored at room temperature is stable for 48 h.

Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization

“…This is an important point of note given some of the alternate methodologies deployed in the literature and the conclusions drawn as a result. Stability data taken from previous studies 34,35 show that DOX is chemically broken down when stored in aqueous solutions. Mayer et al 34 observed a loss of 60% of the original DOX concentration for solutions stored at 37 C for 140 h in normal saline and Ioversol.…”

“…In a separate study, a loss of approximately 70% of the original DOX concentration for solutions stored at 40 C for 168 h in water and Radioselectan Õ was reported. 35 In the current study, it was expected that extracts derived from the 1.4 wt% loaded RC-DEBs at the 168 h elution time point, which had the highest DOX concentration of 2.3 lg/mL in the cell culture media, would have the lowest cell viability. Instead, all DOX-containing extracts at 168 h exhibited similar cell viabilities between 85 and 79%.…”

“…It is unclear why the 168-h extracts showed higher cell viability than the earlier time points, since there was a greater release of DOX at 168 h. This may suggest that DOX: (a) may be unstable at the extract conditions over the entire elution period and/or (b) its interaction with individual components in the RC-DEBs may have resulted in reduced cytotoxicity. 34,35 It may be necessary to evaluate the cell viability of aged solutions with similar concentrations over the same time period in order to understand how exposure to extract conditions may affect cytotoxicity.…”

Separation and Determination of Process-Related Impurities of Erlotinib Using Reverse-Phase HPLC with a Photo-Diode Array Detector

“…A thorough literature survey has indicated several HPLC methods for the determination of erlotinib·HCl in pharmaceutical formulations as well as in biological fluids using ultra-violet and mass spectra detection. [3][4][5][6][7][8] The HPLC method was developed for the assay of erlotinib in the presence of degradation products. 9 The analysis of erlotinib and its metabolites is conducted in rat tissue sections by MALDI quadrupole time-of-flight mass.…”