Stability of emotional dysfunctions? A long-term fMRI study in first-episode schizophrenia

Reske, Martina; Kellermann, Thilo; Habel, Ute; Shah, N. Jon; Backes, Volker; Wilmsdorff, Martina von; Stöcker, Tony; Gäebel, Wolfgang; Schneider, Frank

doi:10.1016/j.jpsychires.2007.02.009

Cited by 60 publications

(51 citation statements)

References 49 publications

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“…Postcentral dysfunction is related to sadness in schizophrenia patients, 41 emotional judgment in healthy patients, 42 and emotional prosody. 43 The right somatosensory and supramarginal gyri are involved in the representation of bodily feelings associated with emotion, according to a simulation model of emotion recognition.…”

Section: Discussionmentioning

confidence: 98%

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Kang¹,

Lee

Kang³

et al. 2012

Alzheimer Disease &Amp; Associated Disorders

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The aim of this study was to identify brain areas related to apathy or depression in patients with Alzheimer disease (AD). Eighty-one AD patients were enrolled in this prospective study. (99m)Tc-HMPAO single photon emission computed tomography was performed to evaluate regional cerebral blood flow (rCBF). According to the Neuropsychiatric Inventory subscores of apathy and depression, 9 patients were classified as clinically significant (cs) depressed and non-cs-apathetic (D+) groups and 9 were classified as cs-apathetic and non-cs-depressed (A+) groups. In addition, 18 patients were classified as age-matched and Mini-Mental State Examination-matched disease control groups (D-, A-). The significance of rCBF differences between groups and the correlation between rCBF and subscores in 81 AD patients were estimated by SPM (uncorrected P < 0.005) analysis. D+ patients had significantly lower perfusion in the right orbitofrontal and inferior frontal gyri than D- patients, whereas A+ patients had this in the right amygdala, temporal, posterior cingulate, right superior frontal, postcentral, and left superior temporal gyri than A- patients. The negatively correlated areas with depression subscores included the left inferior frontal and the right middle frontal gyri and those with apathy subscores included the right temporal and right medial frontal gyri. We suggest that this finding may indicate that apathy and depression in AD patients involve distinct functional circuits.

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Section: Discussionmentioning

confidence: 98%

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Kang¹,

Lee

Kang³

et al. 2012

Alzheimer Disease &Amp; Associated Disorders

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“…Other studies report that it may be due to medication effect (Buchsbaum et al, 1987; Lui et al, 2010). No correlation of CPZ equivalent days with metabolism in basal ganglia suggests an alternate mechanism unrelated to drug effect (Reske et al, 2007; Ursu et al, 2011). Basal ganglia consist primarily of inhibitory projections from prefrontal cortex and are involved in inhibition of inappropriate behavior and guiding towards a desired goal (Gangadhar et al, 2004; Ruppin et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

F-18 fluorodeoxyglucose positron emission tomography study of impaired emotion processing in first episode schizophrenia

Choudhary

Kumar

Tripathi

et al. 2015

Schizophrenia Research

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Background Schizophrenia cases have consistently shown to have behavioural and neurofunctional abnormalities but studies during early course are scarce. The present work assesses the performance of acute first episode schizophrenia cases on correlation of a facial emotion perception task with brain function using Fluorine-18 Fluorodeoxyglucose (FDG) positron emission tomography (PET). Methods Twenty First episode schizophrenia cases and 20 matched healthy controls living in the community were enrolled. For cases, longest duration of illness was one year and treatment with neuroleptic did not exceed two weeks on the day of scan. To measure facial emotion perception (FEP) both groups were administered the Emotion battery from the Penn Computerized Battery followed by PET acquisition. SPM 8 analysis for group differences at p<0.001 was performed. Results Schizophrenia subjects showed hypoactivation of bilateral prefrontal cortices and fusiform gyrii, with significant hyperactivation of bilateral basal ganglia and left precuneus. Positive correlation of metabolism in prefrontal cortex and performance indices on emotions domain was seen. No correlation of CPZ equivalent days with metabolism in basal ganglia was observed. Conclusions The performance of schizophrenia cases on FEP task was significantly impaired in comparison to the control group. Brain regions implicated in emotion processing showed hypometabolism in cases as compared to controls. Failure of schizophrenia cases to optimally recruit brain circuitry may be contributing to deficits on FEP task. These findings suggest inherent deficits in neural circuitry of emotion processing in schizophrenia; devoid of confounding effects of neuroleptics and duration of illness.

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“…The course of positive and negative symptoms was also assessed in several neuroimaging studies (see below and Supplemental Table 2, http://links.lww.com/HRP/A32). Some studies found constant positive symptomatology, 10–12 whereas others 8,9 found improvement over the study interval. Regarding negative symptoms, a similar pattern can be observed, with some studies detecting constancy 9,11,12 and others finding improvement.…”

Section: Positive and Negative Symptomsmentioning

confidence: 98%

“…Some studies found constant positive symptomatology, 10–12 whereas others 8,9 found improvement over the study interval. Regarding negative symptoms, a similar pattern can be observed, with some studies detecting constancy 9,11,12 and others finding improvement. 8,10 These mixed results may reflect differences in statistical power, as the two studies 11,12 that did not detect any improvement (in either positive or negative symptoms) investigated relatively few SZ patients (n = 10 and n = 20, respectively).…”

Section: Positive and Negative Symptomsmentioning

confidence: 98%

The Longitudinal Course of Schizophrenia Across the Lifespan

Heilbronner¹,

Samara

Leucht³

et al. 2016

Harvard Review of Psychiatry

134

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Stability of emotional dysfunctions? A long-term fMRI study in first-episode schizophrenia

Cited by 60 publications

References 49 publications

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

F-18 fluorodeoxyglucose positron emission tomography study of impaired emotion processing in first episode schizophrenia

The Longitudinal Course of Schizophrenia Across the Lifespan

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