Stability of Essential Drugs in the Field: Results of a Study Conducted over a Two-Year Period in Burkina Faso

Ballereau, F.; Prazuck, Thiérry; Schrive, I.; Lafleuriel, M T; Rozec, D; Fisch, A; Lafaix, C

doi:10.4269/ajtmh.1997.57.31

Cited by 46 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plates were incubated at 25 and 37°C for 3 d. Isolates were identi®ed by conventional biochemical tests (Barrow and Feltham 1993;Murray et al 1995).…”

Section: Evaluation Protocolmentioning

confidence: 99%

“…The warm humid conditions that are characteristic of a tropical environment are conducive to the growth of micro-organisms, which are responsible for a number of infectious diseases and the spoilage of food, cosmetic and pharmaceutical products (Bos et al 1989;LeChevallier et al 1996;Ballereau et al 1997;Rosas et al 1997). Developing countries also tend to have lower levels of hygiene and sanitation than industrialized countries, factors that make it possible for such organisms to thrive.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bacteriological quality of skin-moisturizing creams and lotions distributed in a tropical developing country

Okeke

Lamikanra

2001

J Appl Microbiol

View full text Add to dashboard Cite

Aims: To evaluate the bacteriological quality of skin moisturizing products in the South-west part of Nigeria and study factors predisposing their bacterial contamination under tropical conditions. Methods and Results: Viable counts for bacteria exceeded 10 3 cfu ml ±1 or cfu g ±1 in 8 (16á3%) commercially available creams and lotions at time of purchase. Escherichia coli (8), Pseudomonas spp. (7), Staphylococcus spp. (9) and Bacillus spp. (6) were the most commonly recovered bacteria. Following use by volunteers, the proportion of E. coli and other Gramnegative organisms recovered increased. Organic matter, particularly in the absence of preservatives, enhanced survival and growth of bacteria in creams stored under ambient tropical conditions during challenge experiments. Conclusions: Contaminated products are relatively uncommon but some products present a potential health hazard because they are unable to suppress the growth of organisms of likely faecal origin during use. Signi®cance and Impact of the Study: Quality assurance during manufacture, pack size, preservative evaluation, organic matter and water content were identi®ed as factors to be considered during the development of creams and lotions for use in tropical developing countries.

show abstract

“…Plates were incubated at 25 and 37°C for 3 d. Isolates were identi®ed by conventional biochemical tests (Barrow and Feltham 1993;Murray et al 1995).…”

Section: Evaluation Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacteriological quality of skin-moisturizing creams and lotions distributed in a tropical developing country

Okeke

Lamikanra

2001

J Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…lation development. 2,4,7,33 This study shows that probably not all manufacturers comply with this requirement. This is in line with the idea that substandard drug cases are under-reported and are often confused with counterfeit drugs, causing limited understanding of the extent of the problem.…”

Section: Discussionmentioning

confidence: 87%

Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies

Twagirumukiza¹,

Cosijns²,

Pringels³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. The objective of this study was to assess the quality of antihypertensive drugs and to investigate the influence of tropical storage conditions. Drug content and in vitro dissolution tests were performed on 10 test formulations (from Rwanda) and 6 reference formulations (from Belgium or France) after purchase and after 6-month storage under long-term (25 ± 2°C and 60 ± 5% relative humidity [RH]) and accelerated (40 ± 2°C and 75 ± 5% RH) testing conditions. Twenty percent of test formulations were of substandard content at the time of purchase. After 6 months at accelerated testing conditions, 7 of 10 test formulations were substandard in content and 8 were substandard for the combined criteria of drug content and dissolution, whereas no reference drug became substandard. This study shows that, apart from some drugs being already substandard from purchase, accelerated testing conditions (simulating tropical climate) have deleterious effects on the majority of antihypertensive drug formulations found in the Rwandan market.

show abstract

“…This may be especially problematic for anti-malarial. Poor quality anti-malarial may result in under-dosing patients and subsequently lead to treatment failure or drug resistance by the parasite [14] A number of studies have evaluated anti-malarial drug quality and stability under conditions typically found in Africa. Studies used a variety of methods to determine drug quality and stability including storage under simulated tropical conditions, determining the amount of drug released after dissolution of a solid dosage form following chromatography and spectroscopy [15].…”

Section: Introductionmentioning

confidence: 99%

Degradation Study on the Effects of Storage Conditions on Active Ingredient of an ACT- Based Anti-malarial Drugs

Itodo¹

2017

IJBMR

View full text Add to dashboard Cite

Abstract:In this drug storage stability surveillance, we evaluated and compared the effects of different storage temperatures and ventilation conditions on the level of active pharmaceutical ingredient (API) of an ACT-based antimalarial (XYZ) drug formulation. The drug which contains artemether and lumefantrine is marketed by drug vendors in Lafia, Nasarawa state. From the analyses carried out, the concentration of lumefantrine (estimated with UV-Vis spectrophotometer) as well as Artemether (analyzed using HPLC) in the drug shows slightly different values which are statistically insignificant when investigated for the effects of storage temperatures and ventilation conditions. Drugs from pharmaceutical stores equipped with fan without cross ventilation (FNV), fan with inadequate ventilation (OCV), fan with cross ventilation (FCV) and fan with air conditioner (ACF) gave lumefantrine level of 494.30, 438.68, 472.48 and 488.68

show abstract

Stability of Essential Drugs in the Field: Results of a Study Conducted over a Two-Year Period in Burkina Faso

Cited by 46 publications

References 0 publications

Bacteriological quality of skin-moisturizing creams and lotions distributed in a tropical developing country

Bacteriological quality of skin-moisturizing creams and lotions distributed in a tropical developing country

Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies

Degradation Study on the Effects of Storage Conditions on Active Ingredient of an ACT- Based Anti-malarial Drugs

Contact Info

Product

Resources

About