Stability of Glutaraldehyde in Biocide Compositions

Matei, Alina; Pușcaș, Cristina; Patrascu, Iulia; Lehene, Maria; Ziebro, Julia; Scurtu, Florina; Baia, Monica; Porumb, Dan; Tötös, Róbert; Silaghi-Dumitrescu, Radu

doi:10.3390/ijms21093372

Cited by 20 publications

(12 citation statements)

References 24 publications

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“…Here, the hydroxylated Si 3 N 4 surface was taken as a reference spectrum. After APTES-GTA deposition it is possible to observe the appearance of signals in a range between 1100 cm −1 and 1800 cm −1 , which could be related to the presence of NH 2 , CH 2, and CHO groups in the APTES and GTA molecules [ 25 , 26 , 27 ]. After biotin is deposited on the functionalized samples, an enhancement of the same peaks can be observed, since these previously mentioned groups are also present in the biotin molecules [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Functionalization of a Fully Integrated Electrophotonic Silicon Circuit for Biotin Sensing

2023

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Electrophotonic (EPh) circuits are novel systems where photons and electrons can be controlled simultaneously in the same integrated circuit, attaining the development of innovative sensors for different applications. In this work, we present a complementary metal-oxide-semiconductor (CMOS)-compatible EPh circuit for biotin sensing, in which a silicon-based light source is monolithically integrated. The device is composed of an integrated light source, a waveguide, and a p–n photodiode, which are all fabricated in the same chip. The functionalization of the waveguide’s surface was investigated to biotinylate the EPh system for potential biosensing applications. The modified surfaces were characterized by AFM, optical microscopy, and Raman spectroscopy, as well as by photoluminescence measurements. The changes on the waveguide’s surface due to functionalization and biotinylation translated into different photocurrent intensities detected in the photodiode, demonstrating the potential uses of the EPh circuit as a biosensor.

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Section: Resultsmentioning

confidence: 99%

Functionalization of a Fully Integrated Electrophotonic Silicon Circuit for Biotin Sensing

2023

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“…Regarding GA treatments, the interaction of GA with amino groups in proteins and enzymes provides GA with disinfectant properties. Its two aldehyde groups also enable it to be used as a cross-linking agent, creating polymeric and nonpolymeric species while specifically targeting amino groups, which has biocidal effects [ 32 ]. We hypothesized that this mechanism could decrease protease activity, which is better for protein preservation, in comparison to that of the control, whereas protein cross-linking might affect how organic matter is digested.…”

Section: Discussionmentioning

confidence: 99%

Effects of Disinfectants on Larval Growth and Gut Microbial Communities of Black Soldier Fly Larvae

Hao

Liu

Guo

et al. 2023

Insects

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The use of the black soldier fly has been demonstrated to be effective in the treatment of swine manure. Since the outbreaks of ASFV, prevention procedures, including manure disinfection, have changed dramatically. Glutaraldehyde (GA) and potassium peroxymonosulfate (PPMS) have been shown to be effective in the prevention of this pathogen and are thus widely used in the disinfection of swine manures, etc. However, research on the effects of disinfectants in manures on the growth of BSFL and gut microbiota is scarce. The goal of this study was to determine the effects of GA and PPMS on BSFL growth, manure reduction, and gut microbiota. In triplicate, 100 larvae were inoculated in 100 g of each type of manure compound (manure containing 1% GA treatment (GT1), manure containing 0.5% GA treatment (GT2), manure containing 1% PPMS treatment (PT1), manure containing 0.5% PPMS treatment (PT2), and manure without disinfectant (control)). After calculating the larval weight and waste reduction, the larval gut was extracted and used to determine the microbial composition. According to the results, the dry weights of the larvae fed PT1–2 (PT1: 86.7 ± 4.2 mg and PT2: 85.3 ± 1.3 mg) were significantly higher than those of the larvae fed GT1–2 (GT1: 72.5 ± 2.1 mg and GT2: 70 ± 2.8 mg) and the control (64.2 ± 5.8 mg). There was a 2.8–4.03% higher waste reduction in PT1–2 than in the control, and the waste reduction in GT1–2 was 7.17–7.87% lower than that in the control. In a gut microbiota analysis, two new genera (Fluviicola and Fusobacterium) were discovered in PT1–2 when compared to GT1–2 and the control. Furthermore, the disinfectants did not reduce the diversity of the microbial community; rather, Shannon indices revealed that the diversities of GT1–2 (GT1: 1.924 ± 0.015; GT2: 1.944 ± 0.016) and PT1 (1.861 ± 0.016) were higher than those of the control (1.738 ± 0.015). Finally, it was found that both disinfectants in swine manures at concentrations of 1% and 0.5% may be beneficial to the complexity and cooperation of BSFL gut microbiota, according to an analysis of microbial interactions.

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“…Accordingly, the absence of peaks of pure GA in the presence of MNP-GA indicates that GA remains on the MNP surface. 22 Coating with glutaraldehyde was performed to maintain the magnetic nanoparticles' stability, prevent agglomeration and bind the drug.…”

Section: Characterization Of Modified Magnetic Nanoparticlesmentioning

confidence: 99%

Attachment of Idarubicin to Glutaraldehyde-coated Magnetic Nanoparticle and Investigation of its Effect in HL-60 Cell Line

Ulusal

Bozdayı

et al. 2022

International Journal of Chemistry and Technology

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Idarubicin is a chemotherapeutic drug frequently used to treat breast cancer and acute leukemia. This study aimed to immobilize idarubicin on glutaraldehyde (GA)-coated magnetic nanoparticles (MNP-GA) to prepare a drug with high stability and low toxicity. We prefreed MNPS because of their easy synthesis, low cost, and non-toxicity. In the study, magnetite (Fe3O4) nanoparticles were prepared, coated with glutaraldehyde, characterization processes were performed with Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction pattern (XRD), and Conventional transmission electron microscopy (C-TEM) methods, and idarubicin (IDA) was bound. The cytotoxic effects of idarubicin-bound MNP-GA and free idarubicin on HL-60 cell lines were determined by MTT and ATP tests, and IC50 values were calculated. Flow cytometry was used to evaluate apoptosis status, and the expression of MDR1, Puma, NOXA, BAX, Survivin, and BCL-2 genes were measured by the polymerase chain reaction (PCR). It was found that the IC50 decreased between 5 and 7 times with the use of MNP. In PCR tests, the expressions of apoptotic genes increased, while the expressions of MDR1 and anti-apoptotic genes were decreased in the use of MNP. Apoptosis was found to be increased in flow cytometry measurements. The use of MNP systems has reduced drug resistance since it provides controlled release of the drug and prevents its exit from the cell due to its structure.

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Stability of Glutaraldehyde in Biocide Compositions

Cited by 20 publications

References 24 publications

Functionalization of a Fully Integrated Electrophotonic Silicon Circuit for Biotin Sensing

Functionalization of a Fully Integrated Electrophotonic Silicon Circuit for Biotin Sensing

Effects of Disinfectants on Larval Growth and Gut Microbial Communities of Black Soldier Fly Larvae

Attachment of Idarubicin to Glutaraldehyde-coated Magnetic Nanoparticle and Investigation of its Effect in HL-60 Cell Line

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