Stability of lipid emulsions for drug delivery

Washington, C.

doi:10.1016/0169-409x(95)00116-o

Cited by 163 publications

(137 citation statements)

References 38 publications

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“…These complexes therefore are colloidally stable, because the repulsive electrostatic forces between them are proportional to the square of the zeta potential (16). On the other hand in zone B, the complexes close to neutral aggregated, because Van der Waals forces clumped them together.…”

Section: Resultsmentioning

confidence: 99%

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer

Pitard¹,

Aguerre²,

Airiau³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

145

125

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Gene therapy is based on the vectorization of genes to target cells and their subsequent expression. Cationic amphiphile-mediated delivery of plasmid DNA is the nonviral gene transfer method most often used. We examined the supramolecular structure of lipopolyamine͞plasmid DNA complexes under various condensing conditions. Plasmid DNA complexation with lipopolyamine micelles whose mean diameter was 5 nm revealed three domains, depending on the lipopolyamine͞plasmid DNA ratio. These domains respectively corresponded to negatively, neutrally, and positively charged complexes. Transmission electron microscopy and x-ray scattering experiments on complexes originating from these three domains showed that although their morphology depends on the lipopolyamine͞plasmid DNA ratio, their particle structure consists of ordered domains characterized by even spacing of 80 Å, irrespective of the lipid͞DNA ratio. The most active lipopolyamine͞DNA complexes for gene transfer were positively charged. They were characterized by fully condensed DNA inside spherical particles (diameter: 50 nm) sandwiched between lipid bilayers. These results show that supercoiled plasmid DNA is able to transform lipopolyamine micelles into a supramolecular organization characterized by ordered lamellar domains.

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Section: Resultsmentioning

confidence: 99%

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer

Pitard¹,

Aguerre²,

Airiau³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

145

125

View full text Add to dashboard Cite

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“…It has also been suggested that without stearic stabilization, a nano-particulate system would not be stable even if value is greater than 30 mV (Tadros & Vincent, 1980). A certain thickness of polymer layer is necessary (410 nm) for efficient and complete stearic stabilization (Washington, 1996). According to the theory of DLVO, a system could be regarded as stable if the electrostatic repulsion dominated the attractive Van der Waals forces.…”

Section: Particle Size and Zeta Potential () Analysismentioning

confidence: 99%

A vaginal drug delivery model

et al. 2016

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Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and successfully deliver molecules like itraconazole through SLNs. Optimized SLNs with the given composition was selected for further development into mucoadhesive and thermosensitive gel. Stearic acid and Compritol 888 (1:1, w/w ratio) as lipid, a mixture of 3% Poloxomer 188 and 0.5% sodium taurocholate as surfactant and organic to aqueous ratio of 10:50 was taken. Carbopol 934 and Pluronic F 127 were taken for the development of gel. Optimized gel exhibited a desired gelling temperature (35 C); viscosity (0.920 PaS) and appreciable in vitro drug release (62.2% in 20 h). MTT assay did not show any cytotoxic effect of the gel. When evaluated in vivo, it did not exhibit any irritation potential despite appreciable bioadhesion. A remarkable decrease in CFUs was also observed in comparison with control and marketed formulation when evaluated in rat infection model. Thus, the proposed study defines the challenges for developing a suitable formulation system overcoming the delivery barriers of the vaginal site.

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“…Griseofulvin was chosen as a model drug for this investigation taking into consideration its very low aqueous solubility (Tur, Ching, and Baie 1997), its incomplete absorption (Chiou and Riegelman 1971;Kadir et al 1986), and the lack of charge at neutral pH to ensure the lack of interaction with the surface charge of the droplets (Washington 1996).…”

Section: Introductionmentioning

confidence: 99%

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

et al. 2008

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The effect of oil-in-water submicron emulsion (SE) droplet surface charge on absolute bioavailability of a poorly watersoluble drug (griseofulvin, as model drug) after oral administration was studied in conscious rat. Positively, negatively, and neutrally charged SE were designed and characterized (size, polydispersity index, zeta potential, and pH). Three emulsion formulations, whose compositions included 40% oil phase and differed only in the nature of the emulsifying agent, were retained. Only the positively charged SE showed a higher area under the plasma concentrationtime curve (AUC 0→∞ ) in comparison with the tablet and with the other SE.

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Stability of lipid emulsions for drug delivery

Cited by 163 publications

References 38 publications

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer

A vaginal drug delivery model

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

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