Stability of Metabolic Factor Before and After Bariatric Surgery

Davis, Brandon; Indelicato, Joseph

doi:10.1007/s11695-016-2111-6

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…We acknowledge that these findings seem contradictory. However, it should be noted that weight loss in general is associated with metabolic slowing exemplified by decrease in resting metabolic rate . Slowing of the metabolism results in slower weight loss and a risk of weight regain .…”

Section: Discussionmentioning

confidence: 99%

Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients

et al. 2018

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Elevated brain myo-inositol (m-Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a marker of neuronal integrity, reflecting neuronal loss or metabolic derangement). It is not clear if these changes reverse with weight loss. The intra-gastric balloon (IGB) is an endoscopic bariatric therapy that leads to massive weight loss and improvement of glycemic control. In this study we evaluated if tNAA/tCr and m-Ins/tCr metabolite ratios are affected by weight loss, where tCr is the signal of creatine containing compounds. Twenty-three morbidly obese patients, 12 of them with T2DM (OD) and 11 without T2DM (OB), as well as 11 healthy controls of normal weight (CON), underwent single voxel spectroscopy at 3 T. Spectra were obtained within a region in the left parietal white matter one month before IGB insertion, three months after IGB insertion, and one month after IGB removal. Before IGB insertion, m-Ins/tCr was 15% higher in OD than in OB (p = 0.005) and 12% higher in OD than in CON (p = 0.03). m-Ins/tCr decreased significantly by 8% over the first three months after IGB insertion (p = 0.01) and remained normal after IGB removal. tNAA/tCr was normal in all groups throughout the study, pointing to normal brain metabolism. Normalization of m-Ins/tCr is consistent with remission of neuroinflammation in patients with T2DM. An evaluation of long-term effects of IGB treatment is necessary.

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Section: Discussionmentioning

confidence: 99%

Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients

et al. 2018

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“…than normal weight people, but measurement has been difficult 8-10. A study by Davis and Indelicato 11 demonstrated that even with massive postsurgical weight loss, obese people did not have significant changes in Metabolic Factor. The initial weight for the 18 participants was 326.3 pounds (91.3).…”

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confidence: 99%

Take the stigma out of obesity

Indelicato¹

2016

Arch Med Biomed Res

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Social exclusion, stigma, guilt, and shame have been the cornerstone problems of obesity 1. This guilt and shame caused by societal stigma leads to binge eating, depression, and social exclusion 2. These social sequelae have been fostered by a mistaken general assumption that one size fits all when it comes to weight control, which has led to prejudice, hostility and inappropriate treatment 3. Given the very wide metabolic variation that does occur between individuals, any approach obviously must be tailored to each individual's unique body metabolism. Most weight management approaches consider calories in and calories out since a chronic imbalance in this area leads to weight gain, but individuals are treated by public health professionals as though these differences do not exist. While Resting Metabolic Rate (RMR) comprises 50%-80% of energy expenditure in adults 4 , this key measure of metabolism is seldom used in treatment decisions, nor in advising patients of the possible origins of their weight problems. For the past 10 years, technology has advanced to the point that indirect calorimetry of RMR can be measured cheaply and readily 5. Metabolic Factor (MF) measure was first introduced by Davis et al. 6 This new metric is simply calculated by dividing RMR by current weight. For example, an individual with an RMR of 2,000 and a weight of 200 will have a MF of 10. Davis et al 6 found differences in MF based on people's weight. Obese people had an average MF (with standard deviation in parenthesis) of 8.3 (1.5) while the MF of overweight individuals was 10.6 (1.5) and of normal weight people was 12.8 (1.9). These results point to the possibility that MF may have significant influence on an individual's weight, especially considering the strong negative correlation between MF and weight (r =-0.63). People with a lower Body Mass Index (BMI), between 30 and 40, had slightly higher Metabolic Factors of 8.3. Another study used information taken from a German database of 2,105 people 6. Their overall sample had a Metabolic Factor of 9.3. Individuals with a BMI less than 18 had Metabolic Factors of 11.2 while it was 10.4 for BMI 18-25, 9.1 for BMI 25-30, and 8.1 when BMI was over 30. These results point to Metabolic Factor as a possible strong contributor to a person's weight. According to Foster et al 7 of 80 obese women with an average BMI of 38.9, the Metabolic Factor for this group was 7.6. Studies continue to show that obese people have much slower metabolisms, typically fifty percent slower

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“…The mechanism of action likely involves stimulation of gastric mechanoreceptors triggering short-acting vagal signals to brain regions implicated in satiety [5]. Resting metabolic rate (RMR) is elevated among obese individuals; compared with healthyweight individuals it was shown to decrease with weight loss induced by dietary and/or physical activity interventions [6][7][8][9][10][11][12]. However, increases in RMR of individual patients were reported [13].…”

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confidence: 99%

“…However, increases in RMR of individual patients were reported [13]. RMR divided by current weight (RMR/mass) [10,14] is lower among obese individuals, compared with individuals who are overweight or at normal weight [12]. After diet-restriction therapies accompanied by vigorous physical exercise, RMR/mass was reported to decrease [9] or increase (in an extreme case of 35% loss of initial weight) [7].…”

mentioning

confidence: 99%

“…After diet-restriction therapies accompanied by vigorous physical exercise, RMR/mass was reported to decrease [9] or increase (in an extreme case of 35% loss of initial weight) [7]. After bariatric surgery, RMR/mass was reported to increase [7,15] or no significant changes were reported [12]. Additionally, RMR scaled to fat-free mass (FFM) has been used to describe metabolic changes; reductions in RMR/FFM were reported after bariatric surgery [16].…”

mentioning

confidence: 99%

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Changes in resting metabolic rate and body composition due to intragastric balloon therapy

Gaździńska

Mojkowska

Zieliński

et al. 2020

Surgery for Obesity and Related Diseases

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Stability of Metabolic Factor Before and After Bariatric Surgery

Abstract: This study seems to establish the possibility that metabolic factor is not simply a function of one's current weight, but instead might be a stable characteristic unique to each individual.

Cited by 4 publications

References 7 publications

Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients

Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients

Take the stigma out of obesity

Changes in resting metabolic rate and body composition due to intragastric balloon therapy

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