Stability of parenteral nutrition admixtures containing organic phosphates

Ronchera-Oms, C L; Jiménez, N. V.; Peidro, J

doi:10.1016/s0261-5614(95)80055-7

Cited by 29 publications

(19 citation statements)

References 23 publications

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“…The P group is not fully ionised and therefore much less available for adverse interaction with calcium; therefore precipitation of inorganic calcium phosphate should not occur (23).…”

Section: Discussionmentioning

confidence: 99%

Effect of the Intravenous Lipid Emulsions on the Availability of Calcium when using Organic Phosphate in TPN Admixtures

D.¹,

Chaumeil

Jebnoun³

et al. 2008

Pharm Res

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“…The P group is not fully ionised and therefore much less available for adverse interaction with calcium; therefore precipitation of inorganic calcium phosphate should not occur (23).…”

Section: Discussionmentioning

confidence: 99%

Effect of the Intravenous Lipid Emulsions on the Availability of Calcium when using Organic Phosphate in TPN Admixtures

D.¹,

Chaumeil

Jebnoun³

et al. 2008

Pharm Res

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“…Although sugar 1-phosphates are valuable compounds for highly specialized applications, there appears to be limited need for them as fine chemicals. α-D-Glucose 1-phosphate is used in medicine as a substitute of inorganic phosphate in parenteral nutrition and as supplement in the case of a phosphate deficiency [42]. Therefore, phosphorolysis of a disaccharide substrate is generally of a minor interest in carbohydrate synthesis, except in situations where this conversion is applied to prepare the sugar 1-phosphate donor substrate for another phosphorylase-catalyzed transformation, now carried out in synthesis direction (see later).…”

Section: Novel Applications Of Disaccharide Phosphorylases In Synthesismentioning

confidence: 99%

Carbohydrate synthesis by disaccharide phosphorylases: Reactions, catalytic mechanisms and application in the glycosciences

Luley‐Goedl

Nidetzky

2010

Biotechnology Journal

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Disaccharide phosphorylases are glycosyltransferases (EC 2.4.1.α) of specialized carbohydrate metabolism in microorganisms. They catalyze glycosyl transfer to phosphate using a disaccharide as donor substrate. Phosphorylases for the conversion of naturally abundant disaccharides including sucrose, maltose, α,α‐trehalose, cellobiose, chitobiose, and laminaribiose have been described. Structurally, these disaccharide phosphorylases are often closely related to glycoside hydrolases and transglycosidases. Mechanistically, they are categorized according the stereochemical course of the reaction catalyzed, whereby the anomeric configuration of the disaccharide donor substrate may be retained or inverted in the sugar 1‐phosphate product. Glycosyl transfer with inversion is thought to occur through a single displacement‐like catalytic mechanism, exemplified by the reaction coordinate of cellobiose/chitobiose phosphorylase. Reaction via configurational retention takes place through the double displacement‐like mechanism employed by sucrose phosphorylase. Retaining α,α‐trehalose phosphorylase (from fungi) utilizes a different catalytic strategy, perhaps best described by a direct displacement mechanism, to achieve stereochemical control in an overall retentive transformation. Disaccharide phosphorylases have recently attracted renewed interest as catalysts for synthesis of glycosides to be applied as food additives and cosmetic ingredients. Relevant examples are lacto‐N‐biose and glucosylglycerol whose enzymatic production was achieved on multikilogram scale. Protein engineering of phosphorylases is currently pursued in different laboratories with the aim of broadening the donor and acceptor substrate specificities of naturally existing enzyme forms, to eventually generate a toolbox of new catalysts for glycoside synthesis.

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“…Visual inspection, 9 , 11 , 14 light obscuration particle‐counting techniques, 15 – 17 and optical microscopy (membrane filters 18 – 20 or solutions 21 – 25 ) are the 3 most common particle detection assays. The use of multiple detection methods is often employed to provide a more complete picture of calcium and phosphate compatibility as well 26 – 28 . Overall, the variations in rules and assays lead to an ambiguity that causes difficulty in the comparison and clear interpretation of published compatibility curves.…”

Section: Introductionmentioning

confidence: 99%

Probability‐Based Compatibility Curves for Calcium and Phosphates in Parenteral Nutrition Formulations

Gonyon

Carter

Phillips

et al. 2013

J Parenter Enteral Nutr

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The published methods for creating calcium and phosphate compatibility curves via connecting the highest passing or lowest failing calcium concentrations should be augmented or replaced by probability contours of the entire experimental design to determine zones of formulation incompatibilities. We recommend researchers evaluate their data with logistic regression analysis to help build a more comprehensive probabilistic database of compatibility information.

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Stability of parenteral nutrition admixtures containing organic phosphates

Cited by 29 publications

References 23 publications

Effect of the Intravenous Lipid Emulsions on the Availability of Calcium when using Organic Phosphate in TPN Admixtures

Effect of the Intravenous Lipid Emulsions on the Availability of Calcium when using Organic Phosphate in TPN Admixtures

Carbohydrate synthesis by disaccharide phosphorylases: Reactions, catalytic mechanisms and application in the glycosciences

Probability‐Based Compatibility Curves for Calcium and Phosphates in Parenteral Nutrition Formulations

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