Stability of particle suspensions after fine grinding

Hennart, S.L.A.; Wildeboer, W.J.; Hee, P. van; Meesters, G.M.H.

doi:10.1016/j.powtec.2010.01.010

Cited by 17 publications

(7 citation statements)

References 10 publications

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“…For the same reasons, the viscosity of the ground suspension often increases [13] and this affects the ability of the particles to be broken. Also, a lot of work focuses on the research of grinding additives [14][15][16] or operating conditions able to improve suspension stability during the grinding process [17]. In other recent papers, a bead milling process was even used to enhance dispersion stability [18] or to improve other end-use properties [19,20].…”

Section: Introductionmentioning

confidence: 99%

Grinding of calcite suspensions in a stirred media mill: Effect of operational parameters on the product quality and the specific energy

Ouattara

Francès

2014

Powder Technology

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This is an author's version published in: http://oatao.univ-toulouse.fr/20264 To cite this version:Ouattara, Soualo and Frances, Christine Grinding of calcite suspensions in a stirred media mill: Effect of operational parameters on the product quality and the specific energy. (2014) Powder Technology, 255. 89-97. a b s t r a c t a r t i c l e i n f o Keywords: Wet grinding Stirred media mill Particle size RheologyThis paper investigates the production of calcite suspensions by a wet grinding process in a stirred media mill. The experimental set-up allows the circulation mode process in the presence of sodium polyacrylate as additive. The influence of different operational parameters on grinding results in terms of particle size distribution and rheological behavior of the suspensions as well as the grinding efficiency is presented. We observe that the specific energy input that leads to a required product quality is not the same. Moreover, analyzing the trend of particle size versus the specific energy input instead of versus the grinding time, different and opposite conclusions flow from the experiment results. In addition, the effect of particle mean size on the suspension viscosity is presented.

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Section: Introductionmentioning

confidence: 99%

Grinding of calcite suspensions in a stirred media mill: Effect of operational parameters on the product quality and the specific energy

Ouattara

Francès

2014

Powder Technology

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“…According to Stoke's Law , increasing the viscosity of an aqueous vehicle will reduce the sedimentation rate of the suspended particles, thereby increasing the physical stability of the formulation. Criteria for acceptable viscosity levels of liquid oral preparations are not defined in official compendia.…”

Section: Resultsmentioning

confidence: 99%

Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients

García

Manzo

Jiménez-Kairuz

2015

Tropical Med Int Health

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Abstractobjective To develop an extemporaneous 1% benznidazole (BNZ) suspension, with masked taste and adequate stability starting from available commercial tablets. The quality of compounding was evaluated through content uniformity measurement and physical and microbiological stability evaluation, under different storage conditions during 90 days.methods Six batches of 1% BNZ suspension were prepared using safe excipients currently available in a galenic area of Hospital Pharmacy and then stored at 5 and 25°C for 90 days. The BNZ content was determined by UV spectrophotometry. Physical stability was defined as the absence of colour, odour and/or flavour changes and the re-suspension of solid phase by a reasonable amount of simple 15-s shaking. The compliance with microbiological attributes of non-sterile pharmaceutical products was also evaluated.results An oral liquid suspension, containing 1% of BNZ, was developed from commercially available BNZ tablets. The formulations stored for 90 days were easily re-dispersed after a simple 15-s shaking, ensuring the pouring of a liquid volume containing the desired dose of BNZ. All samples were within the acceptable range of BNZ concentration with minimal standard deviations. There were no detectable changes in colour, odour, viscosity, pH and microbial growth, complying with official quality requirements. The quality attributes were not affected by storage, room or refrigeration conditions or by the frequent opening or closing of the multidose containers.

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“…This could be probably due to increase in energy barrier with an increase in electrostatic repulsion as indicated by higher values of zeta potential as explained by Hennart et al (2010) based on the DLVO theory. We have shown that particles in the suspension could be effectively redispersed by application of mild force even though particles were settled in the suspension.…”

Section: Discussionmentioning

confidence: 98%

Influence of pH on the Stability of Alumina and Silica Nanosuspension Produced by Wet Grinding

Patel

Chakraborty

Murthy

2015

Particulate Science and Technology

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Effects of suspension pH on stability and surface properties of alumina and silica nanosuspension were investigated. Nanosuspensions of alumina and silica used in the present study were produced by wet grinding in stirred media mill. The electrostatic stabilization of two types of nanosuspension was conducted by zeta potential and turbiscan analysis as a function of pH. The long term stability analysis of alumina and silica nanosuspension was investigated using an optical analyzer. It was observed that particles gradually aggregated and settled with storage time and can be easily redispersed by mere shaking of suspensions under desirable pH conditions. Transmission electron microscopy images obtained at different suspension pH for both alumina and silica nanoparticles shows that the state of aggregation is highly dependent on pH and found to affect particles morphology.

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Stability of particle suspensions after fine grinding

Cited by 17 publications

References 10 publications

Grinding of calcite suspensions in a stirred media mill: Effect of operational parameters on the product quality and the specific energy

Grinding of calcite suspensions in a stirred media mill: Effect of operational parameters on the product quality and the specific energy

Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients

Influence of pH on the Stability of Alumina and Silica Nanosuspension Produced by Wet Grinding

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