Stability of Pharmaceuticals

Mollica, Joseph A.; Ahuja, Satinder; Cohen, Jerold

doi:10.1002/jps.2600670405

Cited by 47 publications

(10 citation statements)

References 205 publications

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“…The minimum standard of acceptable concentration for pharmaceuticals is 90% of the label claim. 3 Our study shows that lidocaine and epinephrine retained greater than 90% of the initial concentrations 2 weeks after buffering if kept at refrigerated temperature (0-4°C). The pH of five different lots of lidocaine 2% with epinephrine 1 : 100,000 (Elkins-Sinn) was measured in this study.…”

Section: Discussionmentioning

confidence: 59%

“…The stability of lidocaine must be maintained at acceptable levels to determine accurately the amount of lidocaine given to a patient. The minimum standard of acceptable concentration for pharmaceuticals is 90% of the label claim 3 . Our study shows that lidocaine and epinephrine retained greater than 90% of the initial concentrations 2 weeks after buffering if kept at refrigerated temperature (0–4°C).…”

Section: Discussionmentioning

confidence: 69%

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Stability of Buffered Lidocaine and Epinephrine Used for Local Anesthesia

Larson

Ragi

Swandby

et al. 1991

The Journal of Dermatologic Surgery and Oncology

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Buffered lidocaine has been recently recommended for local anesthesia, as there is less pain on injection of the buffered solution. Reduced pain on injection of lidocaine and epinephrine buffered to a neutral pH was confirmed in 20 subjects (P less than .01). Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at 25 degrees C. Buffered epinephrine fell to 1.34% of its initial concentration under similar conditions. Buffered lidocaine and epinephrine maintained 94.54% and 82.04%, respectively, of their initial concentrations after 4 weeks when refrigerated at 0-4 degrees C. Both lidocaine and epinephrine maintained greater than 90% concentration 2 weeks after buffering when stored at 0-4 degrees C. This permits batch buffering of lidocaine with epinephrine and storage for periods up to 2 weeks when properly refrigerated.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 69%

Stability of Buffered Lidocaine and Epinephrine Used for Local Anesthesia

Larson

Ragi

Swandby

et al. 1991

The Journal of Dermatologic Surgery and Oncology

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“…Generally, stability is affected by dosage form. Liquids are less stable than tablets (Mollica et al, 1978). However, Figure 6 shows that the results for the imported samples were significantly different from those for the locally manufactured samples.…”

Section: Discussionmentioning

confidence: 87%

Quality evaluation of iron-containing food supplements in the Palestinian market

et al. 2021

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Iron is widely used to treat anemia and is prescribed or sold as an over-the-counter drug and food supplement in the local market as well as community pharmacy. The iron supplements available in the Palestinian market were tested for their claimed iron content (% assay) and microbial contamination. Altogether, 18 samples of different pharmaceutical dosage forms were collected from the Palestinian market. These samples represented both local and international markets. The actual iron content in the sample products was determined using potentiometric titration and atomic absorption methods. Moreover, bacterial and fungal contaminations were tested according to international pharmacopeial methods. Results revealed that 72% of the tested samples failed the test, and most of them exceeded the standard limit. The results varied according to source and dosage form. This shows that the iron supplements in the Palestinian markets do not meet the international standard allowable limits. Responsible authorities must take an urgent action. In particular, the Ministry of Health should take corrective actions, such as monitoring the registration and performing regular quality checks on imported and local products.

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“…Physical degradation can also occur in the form of denaturation of protein immunogens resulting in the loss of conformationally dependent epitopes, such as was observed for another HIV-l gpl20-based vaccine (Haigwood et al, 1992). To better understand the factors affecting the stability of subunit vaccines design, we recommend several excellent reviews on protein stability in parenteral formulations covering general stability concerns for pharmaceuticals (Mollica et al, 1978;Manning et al, 1989), effects of formulation stabilizers on peptide stability (Wang and Hanson, 1988), and protein degradation pathways (Chen, 1988). Here, we briefly summarize only the major degradation pathways for both the immunogens and several adjuvants.…”

Section: Vaccine Formulation Stabilitymentioning

confidence: 99%