Stability of Reference Thromboplastins

Loeliger, E.A.; Bangham, D. R.; Perkins, F. T.

doi:10.1016/s0140-6736(77)92680-0

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…Blood films were prepared from fresh blood and stained by Leishman's stain. Coagulation studies were done mostly as described by Loeliger [1].…”

Section: Hematological Investigationsmentioning

confidence: 99%

A Clinical and Therapeutic Appraisal in Hemophilia-A

Singh¹,

Singh²

2016

SJAMS

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The hemorrhagic diseases present a complex problem in medicine, for they are often difficult to diagnose and troublesome to manage. Understanding of structure of various coagulation factors and its genetic control, biological and immunological properties has revolutionized the management of coagulation disorders. Hemophilia A occupies a unique position among the hemorrhagic diseases. The present study centers on the critical evaluation of Hemophilia A patients. Attempt was also made to follow the cases carefully in order to study the natural history of disorder and to assess the response on treatment. The major clinical presentation of our patients was due to bleeding into Joints. Knee joint was the most common site of involvement, a major source of distress, incapacitation, and was showing gross deformity in 25% of cases. Recurrent gum bleeding, was a universal complaint and responsible for a sizeable number of hospital visits by hemophiliacs, surpassed only by joint problems in total burden on hemophilic patients. All the hemophiliacs had prolonged KCCT. WBCT was normal in 35% of cases. Thromboplastin generation test confirmed the type of Hemophilia. Factor VIII is expansive and financial constrain was the main limiting factor in treatment of Hemophiliacs. Inj. Factor VIII was given for episodes of bleeding into joints, bleeding into muscle, traumatic bleeding and intracranial bleeding. Acute hemarthroses was treated with factor transfusion and immobilization. For chronic hemophilic arthropathy emphasis was focused on physiotherapy specially in form of active exercises. Difficulty was experienced in continuing the programme because of super imposed episodes of acute bleeding into joint.

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“…Blood films were prepared from fresh blood and stained by Leishman's stain. Coagulation studies were done mostly as described by Loeliger [1].…”

Section: Hematological Investigationsmentioning

confidence: 99%

A Clinical and Therapeutic Appraisal in Hemophilia-A

Singh¹,

Singh²

2016

SJAMS

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“…The target anticoagulant range was 2.8-4.8 INR (27). Individual dose adjustments were guided by the prothrombin time measurements obtained at regular intervals at one of the nineteen participating anticoagulant clinics, the Thrombosis Centres.…”

Section: Oral Anticoagulation and Dose Adjustmentmentioning

confidence: 99%

Assessment of Therapeutic Quality Control in a Long-Term Anticoagulant Trial in Post-Myocardial Infarction Patients

Azar

Deckers²,

Rosendaal³

et al. 1994

Thromb Haemost

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SummaryVarious methods have been described to evaluate efficacy of anticoagulant therapy using the international normalized ration (INR). We compared the following approaches: (1) total INR’s or the most recent measurement; (2) percent time within therapeutic range, with INR changing directly or halfway between visits; and (3) total observation time assuming INR changing linearly. The study population comprised 1700 post myocardial infarction patients. Treatment comprised 3725 patient-years. There were 61,471 INR assessments with target therapeutic level of 2.8–4.8. Acenocoumarol as well as phenprocoumon were employed. Therapeutic achievement in the first months of treatment was low: less than 60% of INR’s were in range. Treatment stabilized after 6 months. Patients on acenocoumarol were within range 70% of the time compared to 80% for phenprocoumon. Method 3 is preferred because it incorporates time and is capable of calculating incidence rates at different INR levels. Our findings call for an urgent improvement of standard of anticoagulant control in the first months following commencement of treatment.

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