Stability of somatostatin in total parenteral nutrition

Montoro, J. A.; Galard, R.; Catalán, Rosa; Martínez, Jean; Salvador, Pollyanna A.; Sabı́n, Pilar

doi:10.1007/bf01967824

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Secondly, somatostatin has a very short biological half-life; a study in rats showed rapid disappearance of somatostatin from circulation ( t 1/2 = 1 min), followed by slow clearance from skin and muscle [ 19 ]. At the same time, in humans, it is about t 1/2 = 2–3 min [ 20 ]. It has been proposed that proteases are responsible for the rapid degradation of this hormone through catabolism [ 19 ].…”

Section: Characteristics Of Cs In Animalsmentioning

confidence: 99%

Coated cysteamine, a potential feed additive for ruminants — An updated review

Yaqoob,

Hou,

Zhe

et al. 2024

Anim Biosci

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For sustainable development, better performance, and less gas pollution during rumen fermentation, there is a need to find a green and safe feed additive for ruminants. Cysteamine (CS) is a biological compound naturally produced in mammalian cells. It is widely used as a growth promoter in ruminants because of its ability to control hormone secretions. It mainly controls the circulating concentration of somatostatin and enhances growth hormone production, leading to improved growth performance. CS modulates the rumen fermentation process in a way beneficial for the animals and environment, leading to less methane production and nutrients loss. Another beneficial effect of using CS is that it improves the availability of nutrients to the animals and enhances their absorption. CS also works as an antioxidant and protects the cells from oxidative damage. In addition, CS has no adverse effects on bacterial and fungal alpha diversity in ruminants. Dietary supplementation of CS enhances the population of beneficial microorganisms. Still, no data is available on the use of CS on reproductive performance in ruminants, so there is a need to evaluate the effects of using CS in breeding animals for an extended period. In this review, the action mode of CS was updated according to recently published data to highlight the beneficial effects of using CS in ruminants.

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Section: Characteristics Of Cs In Animalsmentioning

confidence: 99%

Coated cysteamine, a potential feed additive for ruminants — An updated review

Yaqoob,

Hou,

Zhe

et al. 2024

Anim Biosci

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“…Analogs of this drug have been investigated before, [11][12][13] but, to our knowledge, no stability studies have been performed with the parent molecule somatostatin, except for one publication reporting the loss of peptide in solutions for total parenteral nutrition. [14] Systematic investigations are, therefore, needed in order to gain more information on factors influencing the stability of this particular drug and of peptides in general. These data are essential for rational dosage form development, the design of stability studies, and shelf-life predictions, and they should result in a facilitated and accelerated development of suitable formulations, a prerequisite to obtain the desired pharmacological effect.…”

Section: Introductionmentioning

confidence: 99%

Degradation Kinetics of Somatostatin in Aqueous Solution

Herrmann

Bodmeier

2003

Drug Development and Industrial Pharmacy

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The degradation kinetics of somatostatin (somatotropin release inhibiting factor), a cyclic tetradecapeptide, was investigated as a function of temperature, pH, ionic strength, buffer type, and buffer concentration. In addition, the effect of different container materials in which the solutions were stored and the presence of an antimicrobial agent for in vitro use was examined. The degradation of somatostatin followed first-order kinetics under all investigated conditions. The pH-stability profile showed a well-defined stability optimum around pH 3.7. The degradation was accelerated at higher buffer concentrations, phosphate buffer being significantly more detrimental than acetate buffer. The ionic strength and the drug concentration had virtually no effect on the degradation rate. When general purpose glass vials were used as storage containers, degradation was faster due to release of alkali from the container material. The solution properties, i.e., pH, buffer type, buffer capacity, and the experimental setup such as container material and sterile conditions need to be carefully selected or maintained, in order to avoid accelerated degradation.

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