Stability of topical erythromycin formulations

Vandenbossche, Geert; Vanhaecke, Erwin; Muynck, C. De; Remon, J.P.

doi:10.1016/0378-5173(91)90432-n

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…The pH value of obtained hydrogels was in the range of 8.5–8.59 and was only a little higher compared with hydrogel without dendrimers. The stability of EM is pH dependent; at pH < 7.0, EM is unstable and the optimal pH for semisolid EM preparations is between 7–8.5 [ 25 , 26 ]. Therefore, obtained pH values should not affect its degradation.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin

Wróblewska

Winnicka

2015

IJMS

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Polyamidoamine dendrimers (PAMAM) represent a new class of hyperbranched, monodisperse, three-dimensional polymers with unique properties, which make them very promising carriers of antimicrobial agents. The present study aimed to evaluate the influence of PAMAM-NH2 dendrimers generation two (G2) or three (G3) on physicochemical characteristics and structure of hydrogels with a model antibacterial lipophilic drug—erythromycin—commonly used in topical applications. From the obtained rheograms, it can be concluded that tested hydrogels were non-Newtonian thixotropic systems with shear-thinning behaviour. The dissolution tests revealed that erythromycin was definitely faster released from formulations containing PAMAM-NH2 in concentration and generation dependent manner. However, the addition of PAMAM-NH2 to hydrogels evoked only slight improvement of their antibacterial activity. It was also shown that the structure of hydrogels changed in the presence of PAMAM-NH2 becoming less compact, diversified and more porous. Designed hydrogels with PAMAM-NH2 G2 or G3 were stable stored up to three months at 40 ± 2 °C and 75% ± 5% RH.

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Section: Resultsmentioning

confidence: 99%

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin

Wróblewska

Winnicka

2015

IJMS

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“…To our knowledge, the stability of erythromycin compounded formulation has rarely been studied in the literature. Erythromycin delayed-release tablets have been described as stable for 10 days when stored at 40˚C, [34] and erythromycin topical formulations have been stable for one month when stored at 25˚C [35]. However, in these studies, the quantification methods are not fully described to be stability-indicating as recommend by The International Council for Harmonisation (ICH).…”

Section: Discussionmentioning

confidence: 99%

Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules

Thevin¹,

Curti²,

Benech³

et al. 2023

PLoS ONE

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Objective Erythromycin is a macrolide antibiotic that is also prescribed off-label in premature neonates as a prokinetic agent. There is no oral formulation with dosage and/or excipients adapted for these high-risk patients. Methods Clinical studies of erythromycin as a prokinetic agent were reviewed. Capsules of 20 milligrams of erythromycin were compounded with microcrystalline cellulose. Erythromycin capsules were analyzed using the chromatographic method described in the United States Pharmacopoeia which was found to be stability-indicating. The stability of 20 mg erythromycin capsules stored protected from light at room temperature was studied for one year. Results 20 mg erythromycin capsules have a beyond use date not lower than one year. Conclusion 20 milligrams erythromycin capsules can be compounded in batches of 300 unities in hospital pharmacy with a beyond-use-date of one year at ambient temperature protected from light.

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“…By comparison, the addition of Carbopol 940 yielded formulations with large variations of ERY content, because of its precipitation and aggregation [ 120 ]. The hydroxyethylcellulose gels incorporating dispersed ERY proved an outstandingly good stability, with 90% of the product’s initial activity being preserved following 1 month storage at 25 °C [ 121 ].…”

Section: Gelsmentioning

confidence: 99%

Erythromycin Formulations—A Journey to Advanced Drug Delivery

2022

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Erythromycin (ERY) is a macrolide compound with a broad antimicrobial spectrum which is currently being used to treat a large number of bacterial infections affecting the skin, respiratory tract, intestines, bones and other systems, proving great value from a clinical point of view. It became popular immediately after its discovery in 1952, due to its therapeutic effect against pathogens resistant to other drugs. Despite this major advantage, ERY exhibits several drawbacks, raising serious clinical challenges. Among them, the very low solubility in water and instability under acidic conditions cause a limited efficacy and bioavailability. Apart from this, higher doses promote drug resistance and undesirable effects. In order to overcome these disadvantages, during the past decades, a large variety of ERY formulations, including nanoparticles, have emerged. Despite the interest in ERY-(nano)formulations, a review on them is lacking. Therefore, this work was aimed at reviewing all efforts made to encapsulate ERY in formulations of various chemical compositions, sizes and morphologies. In addition, their preparation/synthesis, physico-chemical properties and performances were carefully analysed. Limitations of these studies, particularly the quantification of ERY, are discussed as well.

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Stability of topical erythromycin formulations

Cited by 9 publications

References 5 publications

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin

Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules

Erythromycin Formulations—A Journey to Advanced Drug Delivery

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