Stability of voriconazole injection in 0.9% sodium chloride and 5% dextrose injections

Stability of extemporaneously prepared voriconazole ophthalmic solution

“…There was no reduction in the measured voriconazole concentration, consistent with what was reported in previous studies (i.e., voriconazole is stable in an acidic environment). 19 Seven days after exposure to heat at 60 °C, a significant peak with a retention time of 3.3 minutes was detected, and the resulting voriconazole concentration was reduced to about 55% of its initial value. Fifteen days after exposure to heat, the degradation peak increased in size, while the voriconazole further decreased to about 22% of the initial concentration.…”

“…There was a negligible degradation peak at 2.4 minutes, with no significant reduction in the voriconazole concentration after exposure to hydrogen peroxide, consistent with previously reported data. 19 Photodiode array analyses of the spectra of all degradation samples ensured the purity of the voriconazole peak (retention time of 4.6 minutes). No peaks for impurities or byproducts overlapped with the voriconazole peak.…”

“…18,19 Practicing pharmacists should exercise caution when preparing extemporaneous voriconazole preparations that may result in the final products having an alkaline pH.…”

“…A modification of the HPLC methods described by Adams and Bergold 18 and Sahraoui et al 19 was adapted for use. The instrumentation included a delivery pump, i a degasser, j an autoinjector, k a column oven, l a photodiode-array ultraviolet spectrophotometric detector, m and a controller n connected to a multiinstrument data acquisition and dataprocessing system.…”

Stability of 1% voriconazole solution in a constant‐rate infusion pump for topical ocular delivery to horses

“…7,8 As voriconazole is not commercially available in an ophthalmic preparation, solutions must be prepared using the IV formulation. 4,9,10 A 1% solution is most commonly used, prepared using the manufacturer instructions for IV administration. A study by Clode et al 4 demonstrated that the highest mean aqueous humor concentration and fewest side effects in horses were achieved by the use of a 1% voriconazole solution.…”