Stability of Δ⁹-tetrahydrocannabinol acetate in e-liquid in the presence of diluents or during vaping

Abstract

The stability of Δ 9 -tetrahydrocannabinol acetate (Δ 9 -THC-OAc) in the presence of diluents or during vaping was investigated. Laboratory-made pure Δ 9 -THC-OAc and glycerol, propylene glycol (PG) , or polyethylene glycol 400 (PEG400) were dissolved in ethanol and subjected to the quantification method for Δ 9 -tetrahydrocannabinol (Δ 9 -THC) recommended by UNODC. The pure Δ 9 -THC-OAc diluted by glycerol, PG, or PEG400 was stored at 40°C for 27 days. A retail liquid product of Δ 9 -THC-OAc containing Δ 9 -THC as an impurity was stored at 80°C for 28 days in the presence of glycerol, PG, or PEG400. A cartridge containing the Δ 9 -THC-OAc liquid was installed in an e-cigarette